Sestrin2 as a potential therapeutic target for cardiovascular diseases

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成果类型：

期刊论文

作者：

Gao, Anbo;Li, Feng;Zhou, Qun*;Chen, Linxi*

通讯作者：

Chen, Linxi;Zhou, Qun

作者机构：

[Gao, Anbo; Chen, Linxi] Univ South China, Hengyang Med Sch, Inst Pharm & Pharmacol, Hengyang 421002, Hunan, Peoples R China.

[Gao, Anbo; Chen, Linxi] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421002, Hunan, Peoples R China.

[Chen, Linxi] Hunan Prov Sci & Technol Dept, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, 28 Western Changshen Rd, Hengyang 421002, Hunan, Peoples R China.

[Li, Feng] Hunan Univ Chinese Med, Med Shcool, Changsha 410000, Hunan, Peoples R China.

[Zhou, Qun] Hunan Univ Med, Sch Pharmaceut Sci, Hunan Prov Key Lab Antibody Based Drug & Intellig, Huaihua 418000, Hunan, Peoples R China.

通讯机构：

[Chen, Linxi] U

[Zhou, Qun] H

Univ South China, Hengyang Med Sch, Inst Pharm & Pharmacol, Hengyang 421002, Hunan, Peoples R China.

Hunan Univ Med, Sch Pharmaceut Sci, Hunan Prov Key Lab Antibody Based Drug & Intellig, Huaihua 418000, Hunan, Peoples R China.

语种：

英文

关键词：

Autophagy;Cardiovascular diseases;Endoplasmic reticulum stress;Oxidative stress;Sestrin2

期刊：

Pharmacological Research

ISSN：

1043-6618

年：

2020

卷：

159

期：

页码：

104990

DOI：

10.1016/j.phrs.2020.104990

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81973326]; Hunan Provincial Natural Science FoundationNatural Science Foundation of Hunan Province [2019JJ40255]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Sestrin2 is a cysteine sulfinyl reductase that plays crucial roles in regulation of antioxidant actions. Sestrin2 provides cytoprotection against multiple stress conditions, including hypoxia, endoplasmic reticulum (ER) stress and oxidative stress. Recent research reveals that upregulation of Sestrin2 is induced by various transcription factors such as p53 and activator protein 1 (AP-1), which further promotes AMP-activated protein kinase (AMPK) activation and inhibits mammalian target of rapamycin protein kinase (mTOR) signaling. Sestrin2 triggers autophagy activity to reduce cellular reactiv...

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