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Sestrin2 as a potential therapeutic target for cardiovascular diseases

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成果类型:
期刊论文
作者:
Gao, Anbo;Li, Feng;Zhou, Qun;Chen, Linxi
通讯作者:
Chen, LX;Zhou, Q
作者机构:
[Gao, Anbo; Chen, Linxi] Univ South China, Hengyang Med Sch, Inst Pharm & Pharmacol, Hengyang 421002, Hunan, Peoples R China.
[Gao, Anbo; Chen, Linxi] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421002, Hunan, Peoples R China.
[Chen, Linxi] Hunan Prov Sci & Technol Dept, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, 28 Western Changshen Rd, Hengyang 421002, Hunan, Peoples R China.
[Li, Feng] Hunan Univ Chinese Med, Med Shcool, Changsha 410000, Hunan, Peoples R China.
[Zhou, Qun] Hunan Univ Med, Sch Pharmaceut Sci, Hunan Prov Key Lab Antibody Based Drug & Intellig, Huaihua 418000, Hunan, Peoples R China.
通讯机构:
[Zhou, Q ] H
[Chen, LX ] U
Univ South China, Hengyang Med Sch, Inst Pharm & Pharmacol, Hengyang 421002, Hunan, Peoples R China.
Hunan Univ Med, Sch Pharmaceut Sci, Hunan Prov Key Lab Antibody Based Drug & Intellig, Huaihua 418000, Hunan, Peoples R China.
语种:
英文
关键词:
adenylate kinase;biological marker;cell protein;mammalian target of rapamycin;Sestrin2 protein;transcription factor Nrf2;unclassified drug;cardiovascular agent;hydroxymethylglutaryl coenzyme A reductase kinase;nuclear protein;SESN2 protein, human;target of rapamycin kinase;transcription factor Nrf2;atrial fibrillation;autophagy (cellular);cardiovascular disease;cell hypoxia;cell protection;endoplasmic reticulum stress;heart failure;heart muscle ischemia;heart protection;homeostasis;human;molecular dynamics;molecular mechanics;nonhuman;priority journal;protein analysis;protein function;protein structure;protein targeting;regulatory mechanism;Review;animal;autophagy;cardiovascular disease;cardiovascular system;drug effect;enzymology;metabolism;molecularly targeted therapy;oxidative stress;pathology;signal transduction;AMP-Activated Protein Kinases;Animals;Autophagy;Cardiovascular Agents;Cardiovascular Diseases;Cardiovascular System;Cell Hypoxia;Humans;Molecular Targeted Therapy;NF-E2-Related Factor 2;Nuclear Proteins;Oxidative Stress;Signal Transduction;TOR Serine-Threonine Kinases
期刊:
Pharmacological Research
ISSN:
1043-6618
年:
2020
卷:
159
期:
1
页码:
104990
基金类别:
This study was supported by Grants from the Natural Science Foundation of China ( 81973326 ) and Hunan Provincial Natural Science Foundation ( 2019JJ40255 ).
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
Sestrin2 is a cysteine sulfinyl reductase that plays crucial roles in regulation of antioxidant actions. Sestrin2 provides cytoprotection against multiple stress conditions, including hypoxia, endoplasmic reticulum (ER) stress and oxidative stress. Recent research reveals that upregulation of Sestrin2 is induced by various transcription factors such as p53 and activator protein 1 (AP-1), which further promotes AMP-activated protein kinase (AMPK) activation and inhibits mammalian target of rapamycin protein kinase (mTOR) signaling. Sestrin2 trig...

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