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Integrating molecular docking and network pharmacology to reveal the molecular mechanisms of Anemarrhena asphodeloides in the treatment of non-small cell lung cancer

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成果类型:
期刊论文
作者:
Xie, Xianshun;Jiang, Yiling;Liu, Sumei;Xie, Changjun
通讯作者:
Xie, CJ;Liu, SM
作者机构:
[Xie, Xianshun; Xie, Changjun] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Oncol Hematol, Hengyang 421001, Hunan, Peoples R China.
[Jiang, Yiling] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Oncol, Hengyang, Hunan, Peoples R China.
[Liu, Sumei] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Emergency, Hengyang, Hunan, Peoples R China.
通讯机构:
[Liu, SM ; Xie, CJ ] U
Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Oncol Hematol, Hengyang 421001, Hunan, Peoples R China.
Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Emergency, Hengyang, Hunan, Peoples R China.
语种:
英文
关键词:
Anemarrhena asphodeloides;Non-small cell lung cancer;Traditional Chinese medicine;Molecular docking;Network pharmacology;Experimental verification
期刊:
Discover Oncology
ISSN:
2730-6011
年:
2025
卷:
16
期:
1
页码:
1399
基金类别:
No funding.
机构署名:
本校为第一且通讯机构
摘要:
Non-small cell lung cancer (NSCLC) is a major cause of global mortality. This study investigated Anemarrhena asphodeloides' potential mechanisms in treating NSCLC through network pharmacology and molecular docking, offering a theoretical basis for future experimental and clinical applications of traditional Chinese medicine in lung cancer therapy. Active compounds of Anemarrhena asphodeloides and their relevant targets were identified by network pharmacology methods. Key targets influenced by Anemarrhena asphodeloides in NSCLC were analyzed using the String 11.0 database to construct a PPI net...

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