Exosomal circ_0032704 confers sorafenib resistance to hepatocellular carcinoma and contributes to cancer malignant progression by modulating the miR-514a-3p/PD-L1 pathway

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Dou, Chengyun;Zhu, Hongbo;Xie, Xia;Huang, Cuiqin;Tan, Hui;...

通讯作者：

Cao, CJ

作者机构：

[Dou, Chengyun; Xie, Xia] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Infect Dis, Hengyang, Hunan, Peoples R China.

[Zhu, Hongbo] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Med Oncol, Hengyang, Hunan, Peoples R China.

[Cao, Chuangjie; Tan, Hui; Huang, Cuiqin] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pathol, Hengyang, Hunan, Peoples R China.

[Cao, Chuangjie; Cao, CJ] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pathol, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Cao, CJ ] U

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pathol, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

circ_0032704;exosomes;HCC;miR-514a-3p;PD-L1;sorafenib

期刊：

Annals of Gastroenterological Surgery

ISSN：

2475-0328

年：

2024

页码：

DOI：

10.1002/ags3.12772

基金类别：

Hunan Provincial Health Commission [202103082238, 202104082246]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Circ_0032704 was overexpressed in sorafenib‐resistant tumor tissues and cells of HCC. The knockdown of circ_0032704 reduced sorafenib resistance, inhibited cell proliferation, migration, and invasion, and enhanced the function of CD8+ T cells. Our study proposed a novel mechanism that circ_032704 exerted these effects by positively regulating PD‐L1 via competitively targeting miR‐514a‐3p. In addition, exosomal circ_0032704 was a promising biomarker in the prediction of sorafenib resistance in HCC development. Abstract Purpose This study aim...

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Exosomal circ_0032704 confers sorafenib resistance to hepatocellular carcinoma and contributes to cancer malignant progression by modulating the miR-514a-3p/PD-L1 pathway

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