Synthesis and Pharmacological Activity of 4\',4\'\'-bit Modified Curcumin Derivatives - 成果

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Synthesis and Pharmacological Activity of 4',4''-bit Modified Curcumin Derivatives

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Tan, Yan;Lang, Jiajia;Tang, Meilun;Mi, Pengbing*;Zheng, Xing

通讯作者：

Mi, Pengbing;Zheng, X

作者机构：

[Tan, Yan; Mi, Pengbing; Tang, Meilun; Zheng, Xing] Univ South China, Dept Pharm, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch,Hunan Prov Key Lab Tumor Microenv, Hengyang, Hunan, Peoples R China.

[Lang, Jiajia] Univ South China, Hengyang Med Coll, Med Instrument & Equipment Technol Lab, Hengyang, Hunan, Peoples R China.

通讯机构：

[Mi, PB; Zheng, X ] U

Univ South China, Dept Pharm, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch,Hunan Prov Key Lab Tumor Microenv, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

curcumin;antiinflammatory activity;antineoplastic activity;antioxidant activity;drug synthesis;nonhuman;Review

期刊：

LETTERS IN DRUG DESIGN & DISCOVERY

ISSN：

1570-1808

年：

2023

卷：

期：

页码：

1884-1897

DOI：

10.2174/1570180819666220806145656

基金类别：

The authors thank the Natural Science Foundation of Hunan (2021JJ80015), Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (0223-0007-000004), Hunan Provincial Hengyang Joint Fund (2020JJ6052), the open fund for innovation platform of Hunan Provincial Department of Education (19K079), the ge-nernal project of Hunan Provincial Department of Education (21C0290, 21C0283), the Undergraduate Research Learning and Innovative Experiment Project (X2019177, X2019179, S201910555143), the Guiding Project of Hengyang Science and Technology Department (S2018F9031015299), Key Laboratory of Tea and Health of Hengyang (202150083704) and the initial funding of University of South China (190XQD142) for financial support.

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Background: Curcumin is a polyphenol compound extracted from plant turmeric with high pharmacological activities. The clinical application of curcumin is limited due to the shortcomings of poor water solubility, instability, and low bioavailability. Objective: Modifying the 4', 4''-bit of curcumin is an effective strategy to improve the pharmacological activity of curcumin. Conclusion: In this review, we focused on the strategy of synthesis, medicinal properties, and structurefunction relationship of 4', 4''-bit modified curcumin derivatives.

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