MiRNA-200a induce cell apoptosis in renal cell carcinoma by directly targeting SIRT1

首页 > 成果 > 详情

认领

导出

下载 Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Fu, Hao;Song, Wenke;Chen, Xuancai;Guo, Tao;Duan, Bin;...

通讯作者：

Huang, Liang;Zhang, Chi

作者机构：

[Duan, Bin; Chen, Xuancai; Wang, Xinxi; Fu, Hao; Tang, Yachun; Guo, Tao] Univ South China, Affiliated Nanhua Hosp, Dept Urol, Hengyang 421002, Hunan, Peoples R China.

[Song, Wenke] Univ South China, Affiliated Nanhua Hosp, Dept Obstet & Gynecol, Hengyang 421002, Hunan, Peoples R China.

[Huang, Liang] Univ South China, Sch Med, Dept Operat Surg, Hengyang 421002, Hunan, Peoples R China.

[Zhang, Chi] Univ South China, Sch Med, Funct Lab Ctr, Dept Pathophisiol, Hengyang 421002, Hunan, Peoples R China.

通讯机构：

[Huang, Liang; Zhang, Chi] U

Univ South China, Sch Med, Dept Operat Surg, Hengyang 421002, Hunan, Peoples R China.

Univ South China, Sch Med, Funct Lab Ctr, Dept Pathophisiol, Hengyang 421002, Hunan, Peoples R China.

语种：

英文

关键词：

MiR-200a;SIRT1;Renal cell carcinoma;Apoptosis

期刊：

Molecular and Cellular Biochemistry

ISSN：

0300-8177

年：

2018

卷：

437

期：

1-2

页码：

143-152

DOI：

10.1007/s11010-017-3102-1

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81100106]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [14C0993]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Accumulating evidence indicates that microRNAs are implicated in tumor initiation and progression through negatively regulating oncogenes or tumor suppressor genes. In the present study, we report that the expression of miR-200a was significantly lower in renal cell carcinoma (RCC) specimens and RCC cell lines. Restoration of miR-200a suppressed cell growth, arrested cell cycle progression, and promoted cell apoptosis in RCC cell lines. We next used qRT-PCR array technology to identify Sirtuin 1 (SIRT1) as one of the downregulated proteins duri...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

MiRNA-200a induce cell apoptosis in renal cell carcinoma by directly targeting SIRT1

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问