期刊论文

Jiang, Zhi-Sheng

英文

Frontiers in Pharmacology

1663-9812

2017

8

JUL

486

10.3389/fphar.2017.00486

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81641019, 81428004, 81470435, 81670429]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2017JJ3277]; Undergraduate Training Programs for Innovation and Entrepreneurship [20161055500, 2016-283-309]; Construct Program of the Basic Medicine Key Discipline in Hunan Province; Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Human Province, China [2008-244]

本校为第一且通讯机构

Ten-eleven translocation-2 (TET2) protein is a DNA demethylase that regulates gene expression through DNA demethylation and also plays important roles in various diseases including atherosclerosis. Endothelial dysfunction represents an early key event in atherosclerotic disease. The cystathionine-γ-lyase (CSE)/hydrogen sulfide (H2S) is a key endogenous system with protective effects on endothelial functions. In this study, we examined how TET2 regulates oxidized low-density lipoprotein (oxLDL)-induced dysfunction of human umbilical vein endoth...