HBV coinfection with HCV alters circulating Tfh cell distribution and impairs HCV neutralizing antibody responses

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成果类型：

期刊论文

作者：

Wen, Bo;Zhang, Jian;Liu, Wenpei;Tang, Ping;Xie, Ting;...

通讯作者：

Qu, Xiaowang

作者机构：

[Xie, Ting; Liu, Ziyan; Tang, Ping; Zhang, Jian; Huang, Liyan; Hu, Yabin; Jin, Kun; Wen, Bo; Qu, Xiaowang; Liu, Wenpei; Zhang, Ping; Niu, Ling] Univ South China, Peoples Hosp Chenzhou 1, Translat Med Inst, 102 Luojiajing, Chenzhou 423000, Hunan, Peoples R China.

[Qu, Xiaowang; Liu, Wenpei] Southern Med Univ, Affiliated Peoples Hosp Chenzhou 1, Chenzhou, Hunan, Peoples R China.

通讯机构：

[Qu, Xiaowang] U

Univ South China, Peoples Hosp Chenzhou 1, Translat Med Inst, 102 Luojiajing, Chenzhou 423000, Hunan, Peoples R China.

语种：

英文

关键词：

hepatitis B surface antigen;neutralizing antibody;hepatitis B surface antigen;hepatitis C antibody;neutralizing antibody;adult;antibody response;Article;cellular distribution;controlled study;female;flow cytometry;hepatitis B;hepatitis C;human;human cell;major clinical study;male;mixed infection;priority journal;Tfh cell;Th1 cell;Th2 cell;blood;comparative study;cytology;drug use;helper cell;Hepacivirus;hepatitis B;Hepatitis B virus;hepatitis C;immunology;middle aged;T lymphocyte subpopulation;virology;virus load;Adult;Antibodies, Neutralizing;Coinfection;Drug Users;Female;Hepacivirus;Hepatitis B;Hepatitis B Surface Antigens;Hepatitis B virus;Hepatitis C;Hepatitis C Antibodies;Humans;Male;Middle Aged;T-Lymphocyte Subsets;T-Lymphocytes, Helper-Inducer;Viral Load

期刊：

Journal of Viral Hepatitis

ISSN：

1352-0504

年：

2019

卷：

期：

页码：

1002-1010

DOI：

10.1111/jvh.13106

基金类别：

This study was supported in part by the Natural Science Foundation of China (grant numbers 81471959, 81501746 and 81401367) and the foundation of The First People's Hospital of Chenzhou (grant number N2018‐001, 2017XJ53,

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Hepatitis C virus (HCV) and hepatitis B virus (HBV) coinfection reciprocally influences viral replication and host defence responses. This study aimed to investigate the impact of HBV coinfection on circulating T follicular helper cell (cTfh) distribution and the HCV neutralizing antibody (nAb) response. HCV neutralizing antibody responses were measured in individuals with HCV monoinfection (n = 83) and HBV/HCV coinfection (n = 78) using the HCV pseudoparticle neutralization assay. The frequencies of cTfh cells and their subsets in HCV monoinfection (n = 34) and HBV/HCV coinfection (n = 30) we...

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HBV coinfection with HCV alters circulating Tfh cell distribution and impairs HCV neutralizing antibody responses

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