This study was supported in part by the Natural Science Foundation of China (grant numbers 81471959, 81501746 and 81401367) and the foundation of The First People's Hospital of Chenzhou (grant number N2018-001, 2017XJ53, N2017-001).
机构署名：
本校为第一且通讯机构
院系归属：
医学院
摘要：
Hepatitis C virus (HCV) and hepatitis B virus (HBV) coinfection reciprocally influences viral replication and host defence responses. This study aimed to investigate the impact of HBV coinfection on circulating T follicular helper cell (cTfh) distribution and the HCV neutralizing antibody (nAb) response. HCV neutralizing antibody responses were measured in individuals with HCV monoinfection (n = 83) and HBV/HCV coinfection (n = 78) using the HCV pseudoparticle neutralization assay. The frequencies of cTfh cells and their subsets in HCV monoinfection (n = 34) and HBV/HCV coinfection (n = 30) we...
