[Xiang, Yuyan] Univ South China, Dept Human Anat, Hengyang, Peoples R China.
[Rao, Xingwang] Wenzhou Med Univ, Dept Otolaryngol Head & Neck Surg, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China.
通讯机构：
[Ren, Jihao] C
Cent S Univ, Dept Otolaryngol Head & Neck Surg, Xiangya Hosp 2, Changsha, Hunan, Peoples R China.
语种：
英文
关键词：
Cholesteatoma;IL-6;STAT3
期刊：
International Journal of Clinical and Experimental Pathology
ISSN：
1936-2625
年：
2014
卷：
7
期：
2
页码：
709-715
机构署名：
本校为其他机构
院系归属：
医学院
摘要：
Interleukin-6 (IL-6) is one of the most important cytokines which has been shown to play a critical role in the pathogenesis of cholesteatoma. In this study, we aimed to investigate the expression of interleukin-6 (IL-6) and phosphorylated signal transducer and activator of transcription 3 (p-STAT3) in middle ear cholesteatoma epithelium in an effort to determine the role of IL-6/JAK/STAT3 signaling pathway in the pathogenesis of cholesteatoma. Immunohistochemistry was used to examine the expression of IL-6 and p-STAT3 in 25 human middle ear cholesteatoma samples and 15 normal external auditor...
