Chemical Genetics of Acetyl-CoA Carboxylases

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成果类型：

期刊论文

作者：

Zu, Xuyu;Zhong, Jing;Luo, Dixian;Tan, Jingjing;Zhang, Qinghai;...

通讯作者：

Cao, Renxian

作者机构：

[Wen, Gebo; Zhong, Jing; Cao, Renxian; Tan, Jingjing; Wu, Ying; Liu, Jianghua; Zu, Xuyu; Zhang, Qinghai] Univ South China, Inst Clin Med, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

[Luo, Dixian] First Peoples Hosp Chenzhou, Inst Translat Med, Chenzhou 423000, Hunan, Peoples R China.

[Luo, Dixian] First Peoples Hosp Chenzhou, Dept Lab Med, Chenzhou 423000, Hunan, Peoples R China.

[Cao, Deliang] So Illinois Univ, Sch Med, Simmons Canc Inst, Dept Microbiol Immunol & Cell Biol, Springfield, IL 62794 USA.

通讯机构：

[Cao, Renxian] U

Univ South China, Inst Clin Med, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

acetyl-CoA carboxylase;fatty acid biosynthesis;ACC chemical genetics;ACC inhibitors;cancer therapy

期刊：

Molecules

ISSN：

1420-3049

年：

2013

卷：

期：

页码：

1704-1719

DOI：

10.3390/molecules18021704

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81272355, 81170807, 81172542]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [11JJ4068]; Education Department of Hunan Province Youth Fund [12B108]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Chemical genetic studies on acetyl-CoA carboxylases (ACCs), rate-limiting enzymes in long chain fatty acid biosynthesis, have greatly advanced the understanding of their biochemistry and molecular biology and promoted the use of ACCs as targets for herbicides in agriculture and for development of drugs for diabetes, obesity and cancers. In mammals, ACCs have both biotin carboxylase (BC) and carboxyltransferase (CT) activity, catalyzing carboxylation of acetyl-CoA to malonyl-CoA. Several classes of small chemicals modulate ACC activity, including cellular metabolites, natural compounds, and che...

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