Glycosylated protein-related microenvironmental features in breast cancer are associated with patient prognosis

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhong, Xiaoxiao*;Han, Jiaxuan;Li, Huan;Shen, Xiangyu;Yu, Bowen;...

通讯作者：

Zhong, Xiaoxiao;Ding, BN;Zhong, XX;Tong, XL

作者机构：

[Shen, Xiangyu; Wu, Wei; Zhong, Xiaoxiao; Li, Jun; Pang, Jin; Ding, Boni; Qian, Liyuan; Chen, Ting; Zhong, XX] Cent South Univ, Dept Breast & Thyroid Surg, Xiangya Hosp 3, Changsha 410000, Hunan, Peoples R China.

[Zhong, Xiaoxiao; Zhong, XX] Cent South Univ, Xiangya Hosp 3, Dept Gen Surg, Changsha 410000, Hunan, Peoples R China.

[Han, Jiaxuan] Cent South Univ, Xiangya Hosp 2, Dept Ophthalmol, Changsha 410000, Hunan, Peoples R China.

[Li, Huan] Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha 410000, Hunan, Peoples R China.

[Yu, Bowen] Cent S Univ, Xiangya Hosp 3, Dept Gastrointestinal Surg, Changsha 410000, Hunan, Peoples R China.

通讯机构：

[Ding, BN ; Tong, XL ; Zhong, XX; Zhong, XX ] C

Cent South Univ, Dept Breast & Thyroid Surg, Xiangya Hosp 3, Changsha 410000, Hunan, Peoples R China.

Cent South Univ, Xiangya Hosp 3, Dept Gen Surg, Changsha 410000, Hunan, Peoples R China.

Cent South Univ, Xiangya Hosp 3, Dept Hematol, Changsha 410000, Peoples R China.

语种：

英文

关键词：

Breast cancer;Tumor microenvironment;Prognostic mode;Glycosylation;Glycosyltransferases;KLRB1

期刊：

Mammalian Genome

ISSN：

0938-8990

年：

2025

卷：

期：

页码：

884-902

DOI：

10.1007/s00335-025-10137-9

基金类别：

This work was supported by the Natural Science Foundation of Hunan Province, China (No. 2022JJ40748), and the Beijing Science and Innovation Medical Development Foundation, China (KC2021-JX-0044-14).

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

The tumor microenvironment (TME) and aberrant glycosylation have been suggested to play key roles in cancer. This study integrated differentially expressed genes (DEGs) and weighted gene coexpression network analysis (WGCNA) to identify tumor microenvironment-related genes and construct a TME-risk prognostic signature (TMERS) through LASSO Cox regression. After batch effect removal, 44 TME-prognosis-related genes (TMEPGs) were identified and classified into three molecular subtypes via K-means clustering. The finalized 22-gene TMERS model demonstrated robust prognostic predictive capacity in G...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Glycosylated protein-related microenvironmental features in breast cancer are associated with patient prognosis

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问