SHARPIN stabilizes estrogen receptor a and promotes breast cancer cell proliferation

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成果类型：

期刊论文

作者：

Zhuang, Ting*;Yu, Sifan;Zhang, Lichen;Yang, Huijie;Li, Xin;...

通讯作者：

Zhuang, Ting;Wang, Hui;Zhu, Jian;Mu, Kun

作者机构：

[Yang, Huijie; Wang, Hui; Yu, Sifan; Li, Anqi; Zhuang, Ting; Wang, H; Zhu, Jian; Li, Xin; Shi, Yuanyuan; Zhang, Lichen; Hou, Yingxiang; Liu, Zhenhua] Xinxiang Med Univ, Sch Lab Med, Res Ctr Immunol, Xinxiang, Henan, Peoples R China.

[Yang, Huijie; Wang, Hui; Yu, Sifan; Li, Anqi; Zhuang, Ting; Wang, H; Zhu, Jian; Li, Xin; Shi, Yuanyuan; Zhang, Lichen; Hou, Yingxiang; Liu, Zhenhua] Xinxiang Med Univ, Henan Collaborat Innovat Ctr Mol Diag & Lab Med, Xinxiang, Henan, Peoples R China.

[Yu, Sifan] Peking Univ, Beijing Canc Hosp & Inst, Sch Oncol,Dept Renal Canc & Melanoma, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing, Peoples R China.

[Zhang, Lichen] Xinxiang Med Univ, Sch Lab Med, Lab Genet Regulators Immune Syst, Xinxiang, Henan, Peoples R China.

[Liu, Zhenhua] Xinxiang Med Univ, Sch Life Sci & Technol, Synthet Biol Remaking Engn & Applicat Lab, Xinxiang, Henan, Peoples R China.

通讯机构：

[Zhuang, T; Wang, H; Zhu, J] X

[Mu, Kun] S

[Zhu, Jian] U

Xinxiang Med Univ, Sch Lab Med, Res Ctr Immunol, Xinxiang, Henan, Peoples R China.

Xinxiang Med Univ, Henan Collaborat Innovat Ctr Mol Diag & Lab Med, Xinxiang, Henan, Peoples R China.

语种：

英文

关键词：

estrogen receptor alpha;protein SHARPIN;ubiquitin protein ligase E3;unclassified drug;Article;cancer growth;cancer prognosis;cellular distribution;controlled study;estrogen receptor positive breast cancer;estrogen responsive element;gene expression;human;immunohistochemistry;protein expression;protein function;protein localization;protein protein interaction;protein stability;RNA sequence;signal transduction;ubiquitination

期刊：

Oncotarget

ISSN：

1949-2553

年：

2017

卷：

期：

页码：

77137-77151

DOI：

10.18632/oncotarget.20368

基金类别：

We thank all the members of Xinxiang Medical University Immunology research center for sharing valuable material and research support. The project was supported by the National Natural Science Foundation of China (No. U1604190, Jian Zhu; No. 81572594, Kun Mu; No. 81602443, Xuefeng Li), the Foundation of Henan Educational Committee (No.16A310014, Jian Zhu; No.17A310025, Ting Zhuang), the Program for Innovative Research Team (in Science and Technology) in University of Henan Province (No.15IRTSTHN025, Hui Wang), the National High Technology Research and Development Program of China (863 Program) (No. 2012AA02A201-1, Xiumin Li), and the Program for Ph. D. starting research funding from Xinxiang Medical University (Jian Zhu and Ting Zhuang). This study is also funded by the innovative practice center of medical graduates, Yashijie medical laboratory institute, School of laboratory medicine, Xinxiang Medical University, and the support project for the Disciplinary group of Oncology and Immunology, Xinxiang Medical University.

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本校为其他机构

院系归属：

医学院

摘要：

Estrogen receptor a is expressed in the majority of breast cancers and promotes estrogen-dependent cancer progression. In our study, we identified the novel E3 ubiquitin ligase SHARPIN function to facilitate ER alpha signaling. SHARPIN is highly expressed in human breast cancer and correlates with ER alpha protein level by immunohistochemistry. SHARPIN expression level correlates with poor prognosis in ER alpha positive breast cancer patients. SHARPIN depletion based RNA-sequence data shows that ER alpha signaling is a potential SHARPIN target. SHARPIN depletion significantly decreases ER alph...

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SHARPIN stabilizes estrogen receptor a and promotes breast cancer cell proliferation

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