The Mitochondrial-Derived Peptide MOTS-c Attenuates Oxidative Stress Injury and the Inflammatory Response of H9c2 Cells Through the Nrf2/ARE and NF-κB Pathways
This work was supported by Funding of the Plan of Science and Technology on Medical and Health in Zhejiang Province (Nos. 2021KY1002, 2022KY312), Ningbo province public welfare project (No. 20211JCGY020364) and Natural Science Foundation of Ningbo (No. 2021J266).
机构署名：
本校为其他机构
院系归属：
医学院
摘要：
Aim: Oxidative stress and the inflammatory response contribute to the progression of cardiovascular disease. The present study aimed to investigate whether the mitochondrial-derived peptide MOTS-c could alleviate H2O2-induced oxidative stress and inflammatory status in H9c2 cells through activation of nuclear factor erythroid 2-related Factor 2 (Nrf2)/antioxidative response element (ARE) and inhibition of the NF-κB pathway. Methods: Rat H9c2 cardiomyocytes were obtained, and 10, 20 or 50 μM MOTS-c was pretreated for 24 h before treatment with...
