STGC3 inhibits xenograft tumor growth of nasopharyngeal carcinoma cells by altering the expression of proteins associated with apoptosis

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成果类型：

期刊论文

作者：

Qiu, Qing-chao;Hu, Bo;He, Xiu-pei;Luo, Qiao;Tang, Guo-hua;...

通讯作者：

He, Xiu-sheng

作者机构：

[Tang, Guo-hua; He, Xiu-sheng; Hu, Bo; Luo, Qiao; Long, Zhi-feng; Qiu, Qing-chao] Univ S China, Canc Res Inst, Hengyang 421001, Peoples R China.

[Hu, Bo; Qiu, Qing-chao] Vanderbilt Univ, Dept Med, Nashville, TN USA.

[Chen, Zhu-chu] Cent S Univ, Canc Res Inst, Changsha 410078, Hunan, Peoples R China.

[Hu, Bo] Hunan Environm Biol Polytech Coll, Hengyang, Peoples R China.

[He, Xiu-pei] First Peoples Hosp Yunnan Prov, Dept Otolaryngol, Kunming, Peoples R China.

通讯机构：

[He, Xiu-sheng] U

Univ S China, Canc Res Inst, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

CNE2 cell line;nasopharyngeal carcinoma;nude mouse;STGC3;Tet-on;two-dimensional electrophoresis

期刊：

Genetics and Molecular Biology

ISSN：

1415-4757

年：

2012

卷：

期：

页码：

18-26

DOI：

10.1590/S1415-47572012005000009

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81172575]; Specialized Research Fund for the Doctoral Program of Higher Education of ChinaSpecialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20104324110002]; Hunan Province Natural Sciences Foundation of ChinaNatural Science Foundation of Hunan Province [09JJ3071]; Hunan Province Education Department Foundation of China [08A060]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

STGC3 is a potential tumor suppressor that inhibits the growth of the nasopharyngeal carcinoma cell line CNE2; the expression of this protein is reduced in nasopharyngeal carcinoma compared with normal nasopharyngeal tissue. In this study, we investigated the tumor-suppressing activity of STGC3 in nude mice injected subcutaneously with Tet/pTRE-STGC3/CNE2 cells. STGC3 expression was induced by the intraperitoneal injection of doxycycline (Dox). The volume mean of Tet/pTRE-STGC3/CNE2+Dox xenografts was smaller than that of Tet/pTRE/CNE2+Dox xeno...

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STGC3 inhibits xenograft tumor growth of nasopharyngeal carcinoma cells by altering the expression of proteins associated with apoptosis

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