Fabrication of GSH‐Responsive Poly(Tertiary Amine‐Oxide)‐Based Nanomedicines for Enhanced Anticancer Drug Release

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成果类型：

期刊论文

作者：

Zhang, Xianshuo;Ma, Wei;Wang, Peipei;Hou, Shuo;Niu, Wenxu;...

通讯作者：

Shi, YF;Wei, H

作者机构：

[Zhang, Xianshuo; Shi, YF; Wang, Peipei; Shi, Yunfeng; Hou, Shuo; Niu, Wenxu] Anyang Normal Univ, Henan Prov Engn & Technol Res Ctr Precise Synth Fl, Henan Prov Key Lab New Optoelect Funct Mat, Anyang 455000, Henan, Peoples R China.

[Zhang, Xianshuo; Shi, YF; Wang, Peipei; Shi, Yunfeng; Hou, Shuo; Niu, Wenxu] Anyang Normal Univ, Sch Chem & Chem Engn, Anyang 455000, Henan, Peoples R China.

[Wei, Hua; Ma, Wei; Wei, H; Yu, Cui-Yun] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang 421001, Peoples R China.

[Wei, Hua; Ma, Wei; Wei, H; Yu, Cui-Yun] Univ South China, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.

[Kang, Guiying] Tianshui Normal Univ, Coll Chem Engn & Technol, Tianshui 741000, Gansu, Peoples R China.

通讯机构：

[Wei, H ] U

[Shi, YF ] A

Anyang Normal Univ, Henan Prov Engn & Technol Res Ctr Precise Synth Fl, Henan Prov Key Lab New Optoelect Funct Mat, Anyang 455000, Henan, Peoples R China.

Anyang Normal Univ, Sch Chem & Chem Engn, Anyang 455000, Henan, Peoples R China.

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

micelle, controlled drug release;poly(tertiary amine-oxide);reduction sensitivity;zwitterionic

期刊：

Macromolecular Chemistry and Physics

ISSN：

1022-1352

年：

2024

卷：

225

期：

页码：

2300335-

DOI：

10.1002/macp.202300335

基金类别：

National Natural Science Foundation of China; Natural Science Foundation of Henan Province [232300420408]; Key Research and Development and Promotion Projects of Henan Province [222102230115]; Key Research Projects, Universities of Henan Province [21A150007]; [51473072]; [82304433]

机构署名：

本校为通讯机构

院系归属：

药学与生物科学学院

摘要：

Poly(tertiary amine-oxide)-based polymeric nanocarriers have showed more functionalities than stealthy PEG-based analogs due to the structure of phospholipid affinitive N-oxides groups, which has attracted considerable attention to the synthesis of various zwitterionic copolymers with tertiary amine-oxide grafts for enhanced anticancer drug delivery. However, poly(tertiary amine-oxide)-based amphiphilic copolymers with tumor intracellular microenvironment sensitivities, to the knowledge, have been rarely reported likely due to the lack of a controlled synthetic strategy. Herein, a reducible zw...

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Fabrication of GSH‐Responsive Poly(Tertiary Amine‐Oxide)‐Based Nanomedicines for Enhanced Anticancer Drug Release

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