Salinomycin triggers endoplasmic reticulum stress through ATP2A3 upregulation in PC-3 cells.

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Yunsheng;Li, Fang;Liu, Luogen;Jiang, Hongtao;Hu, Hua;...

通讯作者：

Wang, Yi

作者机构：

[Wang, Yi; Zhang, Yunsheng; Ge, Xin; Liu, Luogen] Univ South China, Clin Res Inst, Affiliated Hosp 2, Hengyang 421001, Peoples R China.

[Zhang, Yunsheng] Clin Res Ctr Breast & Thyroid Dis Prevent Hunan P, Hengyang 421001, Peoples R China.

[Li, Fang] Hunan Polytech Environm & Biol, Coll Nursing, Hengyang 421005, Peoples R China.

[Jiang, Hongtao] Univ South China, Dept Urol, Hosp 2, Hengyang 421001, Peoples R China.

[Hu, Hua] Univ South China, Canc Res Inst, Hosp 2, Hengyang 421001, Peoples R China.

通讯机构：

[Wang, Yi] U

[Wang, Yi] H

Univ South China, Clin Res Inst, Affiliated Hosp 2, Hengyang 421001, Peoples R China.

Hainan Med Univ, Dept Urol, Affiliated Hosp 2, Haikou 570102, Hainan, Peoples R China.

语种：

英文

关键词：

Salinomycin;ATP2A3;ER stress;Ca2+ release;Apoptosis

期刊：

BMC Cancer

ISSN：

1471-2407

年：

2019

卷：

期：

页码：

1-13

DOI：

10.1186/s12885-019-5590-8

基金类别：

Zhengxiang Scholar Program of the University of South China; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81241090]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2018JJ3462, 2016WK2013]; Scientific Research Project of Education Department of Hunan Province [18B278]; Scientific Research Project of Hunan Provincial Health Commission [B2019107]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

BACKGROUND: Salinomycin is a monocarboxylic polyether antibiotic and is a potential chemotherapy drug. Our previous studies showed that salinomycin inhibited cell growth and targeted CSCs in prostate cancer. However, the precise target of salinomycin action is unclear. METHODS: In this work, we analyzed and identified differentially expressed genes (DEGs) after treatment with or without salinomycin using a gene expression microarray in vitro (PC-3 cells) and in vivo (NOD/SCID mice xenograft model generated from implanted PC-3 cells). Western blotting and immunohistochemical staining were used ...

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Salinomycin triggers endoplasmic reticulum stress through ATP2A3 upregulation in PC-3 cells.

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