期刊论文

Research Progress on Targeting Ferroptosis to Prevent and Treat Major Diseases

中文

临床医学进展

2161-8712

2024

14

04

2037-2044

10.12677/acm.2024.1441260

本校为第一机构

铁死亡(Ferroptosis)是一种铁依赖的细胞死亡途径,其特征在于引起脂质过氧化物的积聚,同时过量Fe2 通过芬顿反应(Fenton reaction)氧化细胞膜上不饱和脂肪酸(polyunsaturated fat...展开更多 铁死亡(Ferroptosis)是一种铁依赖的细胞死亡途径,其特征在于引起脂质过氧化物的积聚,同时过量Fe2 通过芬顿反应(Fenton reaction)氧化细胞膜上不饱和脂肪酸(polyunsaturated fatty acids, PUFAs),从而引发铁死亡。已经有报道铁死亡在包括肿瘤、心血管疾病、肝脏疾病等重大疾病中发挥重要的防治作用。本综述总结了铁死亡在肿瘤、心血管疾病、肝脏疾病以及其他疾病中的最新研究进展,并探讨了铁死亡在防治重...

Ferroptosis is an iron-dependent cell death mode, characterized by the accumulation of lipid peroxides and the oxidation of polyunsaturated fatty acids (PUFAs) on the cell membrane by excessive Fe2 through the Fenton reaction, leading to ferroptosis. It has been reporte...MORE Ferroptosis is an iron-dependent cell death mode, characterized by the accumulation of lipid peroxides and the oxidation of polyunsaturated fatty acids (PUFAs) on the cell membrane by excessive Fe2 through the Fenton reaction, leading to ferroptosis. It has been reported that ferroptosis plays an important role in the pr...