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MiR-370 accelerated cerebral ischemia reperfusion injury via targeting SIRT6 and regulating Nrf2/ARE signal pathway

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成果类型:
期刊论文
作者:
Ruan, Zhong-Fan;Xie, Ming;Gui, Shu-Jia;Lan, Fang;Wan, Juan;...
通讯作者:
Li, Yan
作者机构:
[Ruan, Zhong-Fan; Lan, Fang; Wan, Juan; Xie, Ming] Univ South China, Affiliated Hosp 1, Dept Neurol, Hengyang City, Hunan, Peoples R China.
[Gui, Shu-Jia] Univ South China, Affiliated Nanhua Hosp, Dept Neurol, Hengyang City, Hunan, Peoples R China.
[Li, Yan] Univ South China, Affiliated Nanhua Hosp, Dept Anesthesiol, 336 Dongfeng South Rd, Hengyang City, Hunan, Peoples R China.
通讯机构:
[Li, Yan] U
Univ South China, Affiliated Nanhua Hosp, Dept Anesthesiol, 336 Dongfeng South Rd, Hengyang City, Hunan, Peoples R China.
语种:
英文
关键词:
caspase 3;heme oxygenase 1;lactate dehydrogenase;malonaldehyde;microRNA;microrna 370;sirtuin 6;transcription factor Nrf2;unclassified drug;Casp3 protein, rat;caspase 3;glucose;luciferase;microRNA;MIRN370 microRNA, rat;Nfe2l2 protein, rat;nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase;oxygen;sirtuin;sirtuin 6, rat;transcription factor Nrf2;animal cell;animal experiment;animal model;animal tissue;apoptosis;Article;brain infarction;brain tissue;cell damage;cell viability;cerebral ischemia reperfusion injury;controlled study;in vitro study;male;middle cerebral artery occlusion;nonhuman;protein expression;rat;real time polymerase chain reaction;reoxygenation;SH-SY5Y cell line;signal transduction;TUNEL assay;upregulation;animal;base pairing;brain;brain ischemia;cerebral artery disease;drug effect;gene expression regulation;genetics;human;metabolism;nerve cell;nucleotide sequence;pathology;reperfusion injury;reporter gene;signal transduction;Sprague Dawley rat;tumor cell line;Animals;Base Pairing;Base Sequence;Brain;Brain Ischemia;Caspase 3;Cell Line, Tumor;Gene Expression Regulation;Genes, Reporter;Glucose;Humans;Infarction, Middle Cerebral Artery;Luciferases;Male;MicroRNAs;Neurons;NF-E2-Related Factor 2;Oxygen;Poly(ADP-ribose) Polymerases;Rats;Rats, Sprague-Dawley;Reperfusion Injury;Signal Transduction;Sirtuins
期刊:
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
ISSN:
1607-551X
年:
2020
卷:
36
期:
9
页码:
741-749
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Cerebral ischemia reperfusion (CIR) is one of the highly lethal diseases in the world. MicroRNA-370 (miR-370) exerts multiple functions in different diseases. However, further research is needed to investigate the potential role of miR-370 in CIR injury. The in vivo middle cerebral artery occlusion (MCAO) rat model and in vitro oxygen-glucose deprivation/reoxygenation (OGD/R) SH-SY5Y cell model were successfully established to mimic CIR injury. The infarct sizes of brain tissues from rats were evaluated. The relationship between miR-370 and sil...

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