期刊论文

中文

口腔疾病防治

2096-1456

2019

27

9

551-556

10.12016/j.issn.2096-1456.2019.09.002

81301651:国家自然科学基金 2018JJ2015:湖南省自然科学基金 N2019-008:郴州市第一人民医院重点项目

本校为第一机构

目的探讨骨膜蛋白对兔下颌骨快速牵张成骨的促进作用,为临床应用提供实验依据。方法 24只新西兰雄性白兔行牵张成骨手术后,经过3 d的滞留期,以2 mm/d(共计5 d)牵张速率进行快速牵张,随后实验动物被随机分为A组和B组(每组12只)。牵张结束当天开始每天牵张间隙注射含40μg重组骨膜蛋白的0.5 mL生理盐水(B组)或等体积生理盐水为对照组(A组)共8 d。牵张结束后4周和8周,每组随机抽出8只样本全麻下进行CT扫描,应用双能X线吸收法检测骨矿密度和骨矿含量。牵张结束后8周,全部实验动物被处死,每组随机选取6只样本进行micro-CT和组织学检查,剩余样本进行生物力学测试。结果 CT影像提示在牵张结束后4周及8周...

Objective To explore the promoting effect of periostin on rapid distraction osteogenesis of the rabbit mandible and provide experimental evidence for the clinical use of periostin to promote osteogenesis. Methods Twenty-four New Zealand male white rabbits underwent distraction osteogenesis, and after 3 days of retention, they were rapidly stretched at a stretch rate of 2 mm/d(total 5 d). The animals were randomly divided into group A and group B(12 per group). On the last day of the stretch, 0.5 mL of normal saline containing 40 μg of recombin...