BDNF-TrkB pathway mediates antidepressant-like roles of H2S in diabetic rats via promoting hippocampal autophagy

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成果类型：

期刊论文

作者：

Liu, Hai-Yao;Wei, Hai-Jun;Wu, Lin;Liu, Su-Mei;Tang, Yi-Yun;...

通讯作者：

Tang, Xiao-Qing;Zou, Wei

作者机构：

[Tang, Xiao-Qing; Zou, Wei; Liu, Hai-Yao; Liu, Su-Mei; Zhang, Ping; Wu, Lin] Univ South China, Affiliated Nanhua Hosp, Dept Neurol, Hengyang, Peoples R China.

[Wei, Hai-Jun; Wang, Chun-Yan; Tang, Xiao-Qing; Zou, Wei; Liu, Hai-Yao; Liu, Su-Mei; Zhang, Ping; Tang, Yi-Yun; Wu, Lin] Univ South China, Med Coll, Inst Neurosci, 28 W Changsheng Rd, Hengyang, Hunan, Peoples R China.

[Liu, Hai-Yao] Hengyang Ctr Hosp, Dept Neurol, Hengyang, Peoples R China.

[Wei, Hai-Jun; Tang, Xiao-Qing] Univ South China, Affiliated Hosp 1, Inst Neurol, Hengyang, Peoples R China.

[Tang, Xiao-Qing] Univ South China, Med Coll, Dept Physiol, 28 W Changsheng Rd, Hengyang, Hunan, Peoples R China.

通讯机构：

[Tang, Xiao-Qing; Zou, Wei] U

Univ South China, Med Coll, Inst Neurosci, 28 W Changsheng Rd, Hengyang, Hunan, Peoples R China.

Univ South China, Med Coll, Dept Physiol, 28 W Changsheng Rd, Hengyang, Hunan, Peoples R China.

Univ South China, Nanhua Affiliated Hosp, Dept Neurol, 336 E Dongfeng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

autophagy;BDNF-TrkB pathway;depressive-like behaviours;hydrogen sulfide

期刊：

Clinical and Experimental Pharmacology and Physiology

ISSN：

0305-1870

年：

2020

卷：

期：

页码：

302-312

DOI：

10.1111/1440-1681.13201

基金类别：

This work was supported by the National Natural Science Foundation of China (81971267) and the Natural Science Foundation of Hunan province (2019JJ80101, 2019JJ50556, 2019JJ50546). The authors also thank Dr Xiangping Chu (University of Missouri-Kansas City, USA) for his critical reading.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Hydrogen sulfide (H2S) plays antidepressant-like roles in diabetic rats. However, the underlying mechanisms remain unclear. Brain-derived neurotropic factor (BDNF), a neurotrophic factor, plays important regulatory roles in depression by its high-affinity tropomysin-related kinase B (TrkB) receptor. Autophagy also is implicated in modulation of depression. Previous work confirmed the modulatory roles of H2S in BDNF protein expression and autophagy. Thus, in this study, we explored whether the BDNF-TrkB pathway mediates the antidepressant-like effects of H2S in diabetic rats and whether this pr...

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BDNF-TrkB pathway mediates antidepressant-like roles of H2S in diabetic rats via promoting hippocampal autophagy

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