BDNF/TrkB Pathway Mediates the Antidepressant-Like Role of H2S in CUMS-Exposed Rats by Inhibition of Hippocampal ER Stress

首页 > 成果 > 详情

认领

导出

下载 Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wei, Le;Kan, Li-Yuan;Zeng, Hai-Ying;Tang, Yi-Yun;Huang, Hong-Lin*;...

通讯作者：

Huang, Hong-Lin;Tang, Xiao-Qing

作者机构：

[Tang, Xiao-Qing; Huang, Hong-Lin; Wei, Le] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Wang, Chun-Yan; Tang, Xiao-Qing; Zou, Wei; Kan, Li-Yuan; Wei, Le; Zeng, Hai-Ying; Tang, Yi-Yun; Xie, Ming; Zhang, Ping] Univ South China, Med Coll, Dept Physiol, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Wang, Chun-Yan; Tang, Xiao-Qing; Zou, Wei; Kan, Li-Yuan; Wei, Le; Zeng, Hai-Ying; Tang, Yi-Yun; Xie, Ming; Zhang, Ping] Univ South China, Med Coll, Inst Neurosci, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Tang, Xiao-Qing; Kan, Li-Yuan; Xie, Ming] Univ South China, Affiliated Hosp 1, Dept Neurol, Hengyang 421001, Hunan, Peoples R China.

[Zou, Wei; Zeng, Hai-Ying; Zhang, Ping] Univ South China, Nanhua Affiliated Hosp, Dept Neurol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Huang, Hong-Lin; Tang, Xiao-Qing] H

Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Institute of Pharmacy and Pharmacology, University of South China, 28 West Changsheng Road, Hengyang, 421001, Hunan, People's Republic of China.

Department of Physiology and Institute of Neuroscience, Medical College, University of South China, 28 W Changsheng Road, Hengyang, 421001, Hunan, People's Republic of China.

Department of Neurology, The First Affiliated Hospital, University of South China, Hengyang, 421001, Hunan, People's Republic of China.

语种：

英文

关键词：

BDNF/TrkB pathway;Chronic unpredictable mild stress;Depression;Endoplasmic reticulum stress;Hydrogen sulfide

期刊：

NeuroMolecular Medicine

ISSN：

1535-1084

年：

2018

卷：

期：

页码：

252-261

DOI：

10.1007/s12017-018-8489-7

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81471310, 81371485]; Major Research Topics of the Health and Family Planning Commission of Hunan province [A2017020]; Key Projects of the Education Department of Hunan province [17A187]; Hunan Provincial Innovation Foundation for Postgraduate [CX2017B545]

机构署名：

本校为第一机构

院系归属：

医学院

药学与生物科学学院

摘要：

Our previous works have shown that hydrogen sulfide (H2S) significantly attenuates chronic unpredictable mild stress (CUMS)-induced depressive-like behaviors and hippocampal endoplasmic reticulum (ER) stress. Brain-derived neurotrophic factor (BDNF) generates an antidepressant-like effect by its receptor tyrosine protein kinase B (TrkB). We have previously found that H2S upregulates the expressions of BDNF and p-TrkB in the hippocampus of CUMS-exposed rats. Therefore, the present work was to explore whether BDNF/TrkB pathway mediates the antidepressant-like role of H2S by blocking hippocampal ...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

BDNF/TrkB Pathway Mediates the Antidepressant-Like Role of H2S in CUMS-Exposed Rats by Inhibition of Hippocampal ER Stress

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问