BDNF/TrkB Pathway Mediates the Antidepressant-Like Role of H2S in CUMS-Exposed Rats by Inhibition of Hippocampal ER Stress

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作者信息关键词期刊信息会议信息基础信息归属信息摘要

成果类型：

期刊论文、会议论文

作者：

Wei, Le;Kan, Li-Yuan;Zeng, Hai-Ying;Tang, Yi-Yun;Huang, Hong-Lin*;...

通讯作者：

Huang, Hong-Lin;Tang, Xiao-Qing

作者机构：

[Tang, Xiao-Qing; Huang, Hong-Lin; Wei, Le; Huang, HL; Tang, XQ] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Wang, Chun-Yan; Tang, Xiao-Qing; Zou, Wei; Kan, Li-Yuan; Wei, Le; Zeng, Hai-Ying; Tang, Yi-Yun; Xie, Ming; Zhang, Ping] Univ South China, Med Coll, Dept Physiol, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Wang, Chun-Yan; Tang, Xiao-Qing; Zou, Wei; Kan, Li-Yuan; Wei, Le; Zeng, Hai-Ying; Tang, Yi-Yun; Xie, Ming; Zhang, Ping] Univ South China, Med Coll, Inst Neurosci, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Tang, Xiao-Qing; Kan, Li-Yuan; Xie, Ming] Univ South China, Affiliated Hosp 1, Dept Neurol, Hengyang 421001, Hunan, Peoples R China.

[Zou, Wei; Zeng, Hai-Ying; Zhang, Ping] Univ South China, Nanhua Affiliated Hosp, Dept Neurol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Huang, HL; Tang, XQ; Tang, Xiao-Qing] U

Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Med Coll, Dept Physiol, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Med Coll, Inst Neurosci, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 1, Dept Neurol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

brain derived neurotrophic factor;caspase 12;CCAAT enhancer binding protein;glucose regulated protein 78;hydrogen sulfide;k 252a;antidepressant agent;Bdnf protein, rat;brain derived neurotrophic factor;brain derived neurotrophic factor receptor;carbazole derivative;hydrogen sulfide;indole alkaloid;nerve protein;staurosporine aglycone;TrkB protein, rat;adult;animal experiment;antidepressant activity;Article;chronic unpredictable stress;controlled study;endoplasmic reticulum stress;forced swim test;hippocampus;immobility time;locomotion;male;nerve cell inhibition;neuroprotection;nonhuman;novelty suppressed feeding test;open field test;priority journal;protein cleavage;protein expression;rat;signal transduction;tail suspension test;Western blotting;animal;antagonists and inhibitors;biosynthesis;drug effect;drug therapy;endoplasmic reticulum stress;exploratory behavior;gene expression regulation;genetics;hippocampus;mental stress;metabolism;motor activity;physiology;randomization;signal transduction;Sprague Dawley rat;swimming;Animals;Antidepressive Agents;Brain-Derived Neurotrophic Factor;Carbazoles;Endoplasmic Reticulum Stress;Exploratory Behavior;Gene Expression Regulation;Hippocampus;Hydrogen Sulfide;Indole Alkaloids;Male;Motor Activity;Nerve Tissue Proteins;Random Allocation;Rats;Rats, Sprague-Dawley;Receptor, trkB;Signal Transduction;Stress, Psychological;Swimming

期刊：

NeuroMolecular Medicine

ISSN：

1535-1084

年：

2018

卷：

期：

页码：

252-261

会议名称：

中国生理学会张锡钧基金会第十四届全国青年优秀生理学学术论文交流及评奖会议、中国生理学会第十二届全国青年生理学工作者学术会议

会议时间：

2017-10-20

会议地点：

中国江苏无锡

DOI：

10.1007/s12017-018-8489-7

基金类别：

Acknowledgements This study was supported by Natural Science Foundation of China (81471310, 81371485), the Major Research Topics of the Health and Family Planning Commission of Hunan province (A2017020), the Key Projects of the Education Department of Hunan province (17A187) and Hunan Provincial Innovation Foundation for Postgraduate (CX2017B545).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Our previous works have shown that hydrogen sulfide (H2S) significantly attenuates chronic unpredictable mild stress (CUMS)-induced depressive-like behaviors and hippocampal endoplasmic reticulum (ER) stress. Brain-derived neurotrophic factor (BDNF) generates an antidepressant-like effect by its receptor tyrosine protein kinase B (TrkB). We have previously found that H2S upregulates the expressions of BDNF and p-TrkB in the hippocampus of CUMS-exposed rats. Therefore, the present work was to explore whether BDNF/TrkB pathway mediates the antide...

摘要(中文)：

Accumulating evidences suggest that chronic unpredictable mild stress(CUMS)induced depressive-like behaviors and hippocampal endoplasmic reticulum(ER)stress.Our previous wo...

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BDNF/TrkB Pathway Mediates the Antidepressant-Like Role of H2S in CUMS-Exposed Rats by Inhibition of Hippocampal ER Stress

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