BDNF-TrkB Pathway Mediates Neuroprotection of Hydrogen Sulfide against Formaldehyde-Induced Toxicity to PC12 Cells

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成果类型：

期刊论文

作者：

Jiang, Jia-Mei;Zhou, Cheng-Fang;Gao, Sheng-Lan;Tian, Ying*;Wang, Chun-Yan;...

通讯作者：

Tian, Ying

作者机构：

[Gu, Hong-Feng; Tang, Xiao-Qing; Jiang, Jia-Mei; Gao, Sheng-Lan; Zhou, Cheng-Fang] Univ South China, Coll Med, Dept Physiol, Hengyang 421001, Hunan, Peoples R China.

[Gu, Hong-Feng; Tang, Xiao-Qing; Jiang, Jia-Mei; Gao, Sheng-Lan; Zhou, Cheng-Fang] Univ South China, Coll Med, Inst Neurosci, Hengyang 421001, Hunan, Peoples R China.

[Gu, Hong-Feng; Tang, Xiao-Qing; Jiang, Jia-Mei; Gao, Sheng-Lan] Univ South China, Key Lab Cognit Disorders & Neurodegenerat Dis, Hengyang 421001, Hunan, Peoples R China.

[Tian, Ying] Univ South China, Coll Med, Dept Biochem, Hengyang 421001, Hunan, Peoples R China.

[Wang, Chun-Yan] Univ South China, Coll Med, Dept Pathophysiol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Tian, Ying] U

Univ South China, Coll Med, Dept Biochem, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Apoptosis;Oxidative stress;Cytotoxicity;Protein expression;Formaldehyde;Central nervous system;Enzyme-linked immunoassays;Neuroprotectives

期刊：

PLOS ONE

ISSN：

1932-6203

年：

2015

卷：

期：

页码：

e0119478

DOI：

10.1371/journal.pone.0119478

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81202518, 81200985]; Natural Science Foundation of Hunan Province, ChinaNatural Science Foundation of Hunan Province [11JJ3117, 12JJ9032]; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education MinistryScientific Research Foundation for the Returned Overseas Chinese Scholars [[2011]508]; construct program of the key discipline in Hunan province

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Formaldehyde (FA) is a common environmental contaminant that has toxic effects on the central nervous system (CNS). Our previous data demonstrated that hydrogen sulfide (H2S), the third endogenous gaseous mediator, has protective effects against FA-induced neurotoxicity. As is known to all, Brain-derived neurotropic factor (BDNF), a member of the neurotrophin gene family, mediates its neuroprotective properties via various intracellular signaling pathways triggered by activating the tyrosine kinase receptor B (TrkB). Intriguingly, our previous data have illustrated the upregulatory role of H2S...

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BDNF-TrkB Pathway Mediates Neuroprotection of Hydrogen Sulfide against Formaldehyde-Induced Toxicity to PC12 Cells

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