Partially fluorinated nanoemulsions for 19F MRI-fluorescence dual imaging cell tracking

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成果类型：

期刊论文

作者：

Chen, Kexin;Wu, Tingjuan;Jiang, Mou;Li, Anfeng;Peng, Xingxing;...

通讯作者：

Jiang, Z.-X.;Zheng, X.

作者机构：

[Peng, Xingxing; Li, Anfeng; Wu, Tingjuan; Chen, Kexin; Zheng, Xing] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Grp Lead Compound,Dept Pharm, Hengyang 421001, Peoples R China.

[Peng, Xingxing; Li, Anfeng; Jiang, Zhong-Xing; Wu, Tingjuan; Chen, Kexin; Yang, Zhigang] Wuhan Univ, Hubei Prov Engn & Technol Res Ctr Fluorinated Pha, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China.

[Jiang, Zhong-Xing; Zhou, Xin; Chen, Shizhen; Jiang, Mou] Huazhong Univ Sci & Technol, Chinese Acad Sci, Natl Ctr Magnet Resonance Wuhan,Wuhan Inst Phys &, Wuhan Natl Lab Optoelect,State Key Lab Magnet Res, Wuhan 430071, Peoples R China.

通讯机构：

[Zheng, X.] G

[Jiang, Z.-X.] H

Group of Lead Compound, Department of Pharmacy, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China

语种：

英文

关键词：

(19)F magnetic resonance imaging;Cell tracking;Fluorescence imaging;Nanoemulsions;Paramagnetic effect

期刊：

Colloids and Surfaces B: Biointerfaces

ISSN：

0927-7765

年：

2022

卷：

215

页码：

112493

DOI：

10.1016/j.colsurfb.2022.112493

基金类别：

CRediT authorship contribution statement Kexin Chen: Synthesis, Formulation, Characterization, and Cell study. Tingjuan Wu: Formulation and cell study. Mou Jiang: 1H/13C/19F NMR and 19F MRI. Anfeng Li: Cell culture. Xingxing Peng: Cell culture. Shizhen Chen: Project administration. Zhigang Yang: Project supervision. Xin Zhou: Project design and funding acquisition. Xing Zheng: Writing-original draft. Zhong-Xing Jiang: Project design, Writing-review & editing.

机构署名：

本校为第一机构

院系归属：

药学与生物科学学院

摘要：

Fluorine-19 magnetic resonance imaging (19F MRI) has been a technology of choice for in vivo cell tracking, in which perfluorocarbons (PFCs) nanoemulsions are the most used 19F MRI agents. However, the peculiar physicochemical properties of PFCs may lead to poor cell uptake and misleading cell tracking results. Herein, we employed partially fluorinated aromatic agents to formulate paramagnetic nanoemulsions as novel 19F MRI-fluorescence (FL) dual imaging agents for cell tracking. With the intramolecular π-π interaction, low density and fluori...

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Partially fluorinated nanoemulsions for 19F MRI-fluorescence dual imaging cell tracking

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