Role of mitochondrial fusion proteins MFN2 and OPA1 on lung cellular senescence in chronic obstructive pulmonary disease

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成果类型：

期刊论文

作者：

Li, Chenfei;Liu, Qi;Chang, Qing;Xie, Meiqin;Weng, Jiali;...

通讯作者：

Zhang, Hai;Li, F

作者机构：

[Weng, Jiali; Li, Chenfei; Li, F; Li, Feng; Wang, Xiaohui; Zhang, Hai; Liu, Qi; Xie, Meiqin; Chang, Qing; Li, Mengnan; Zhang, H] Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Sch Med, Dept Pulm & Crit Care Med, 241 West HuaiHai Rd, Shanghai 200030, Peoples R China.

[Chen, Jiani] Univ South China, Coll Publ Hlth, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Huang, Yan] Anhui Med Univ, Sch Pharm, Meishan Rd, Hefei 230032, Anhui, Peoples R China.

[Zhang, Na; Yang, Xiaohua; Wang, Kai] Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Sch Med, Dept Cent Lab, 241 West HuaiHai Rd, Shanghai 200030, Peoples R China.

[Chung, Kian Fan; Adcock, Ian M.] Imperial Coll, Natl Heart & Lung Inst, Airway Dis Sect, Dovehouse St, London SW3 6LY, England.

通讯机构：

[Li, F ; Zhang, H] S

Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Sch Med, Dept Pulm & Crit Care Med, 241 West HuaiHai Rd, Shanghai 200030, Peoples R China.

语种：

英文

关键词：

Chronic obstructive pulmonary disease (COPD);Mitochondrial dynamics;Mitophagy;Lung senescence;Cigarette smoke

期刊：

RESPIRATORY RESEARCH

ISSN：

1465-9921

年：

2023

卷：

期：

页码：

1-17

DOI：

10.1186/s12931-023-02634-9

基金类别：

This work was supported by Shanghai Municipal Health Commission (No. 2020YJZX0115) and National Natural Science Foundation of China (No. 82070041).

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Mitochondrial dysfunction and lung cellular senescence are significant features involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Cigarette smoke (CS) stands as the primary contributing factor to COPD. This study examined mitochondrial dynamics, mitophagy and lung cellular senescence in COPD patients and investigated the effects of modulation of mitochondrial fusion [mitofusin2 (MFN2) and Optic atrophy 1 (OPA1)] on CS extract (CSE)-induced lung cellular senescence. Senescence-associated secretory phenotype (SASP) com...

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Role of mitochondrial fusion proteins MFN2 and OPA1 on lung cellular senescence in chronic obstructive pulmonary disease

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