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CMP-N-acetylneuraminic acid synthetase interacts with fragile X related protein 1

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成果类型:
期刊论文
作者:
Ma, Yun*;Tian, Shuai;Wang, Zongbao;Wang, Changbo;Chen, Xiaowei;...
通讯作者:
Ma, Yun;He, Shuya
作者机构:
[He, Shuya; Li, Wei; Ma, Yun; Tian, Shuai; Yang, Yang; He, SY; Chen, Xiaowei; Wang, Changbo] Univ South China, Dept Biochem & Biol, 28 Western Changshen Rd, Hengyang 421001, Hunan, Peoples R China.
[Wang, Zongbao; He, Shuya; Ma, Yun; He, SY] Univ South China, Inst Pharmaceut & Biol Sci, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Ma, Y; He, SY] U
Univ South China, Dept Biochem & Biol, 28 Western Changshen Rd, Hengyang 421001, Hunan, Peoples R China.
Univ South China, Inst Pharmaceut & Biol Sci, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
acylneuraminate cytidylyltransferase;fragile X mental retardation protein;fragile X related protein 1;ganglioside GM1;sialic acid;unclassified drug;acylneuraminate cytidylyltransferase;FMR1 protein, human;fragile X mental retardation protein;GM1 pentasaccharide;oligosaccharide;protein binding;Article;cell nucleus;cellular distribution;controlled study;cytoplasm;enzyme linked immunosorbent assay;female;gene construct;gene overexpression;gene vector;HeLa cell line;human;human cell;immunofluorescence microscopy;immunoprecipitation;nonhuman;protein expression;protein function;protein localization;protein protein interaction;Saccharomyces cerevisiae;two hybrid system;chemistry;fragile X syndrome;gene expression;genetics;HEK293 cell line;metabolism;protein analysis;protein domain;protein transport;Fragile X Mental Retardation Protein;Fragile X Syndrome;Gene Expression;HEK293 Cells;HeLa Cells;Humans;Immunoprecipitation;N-Acylneuraminate Cytidylyltransferase;Oligosaccharides;Protein Binding;Protein Interaction Domains and Motifs;Protein Interaction Mapping;Protein Transport;Two-Hybrid System Techniques
期刊:
MOLECULAR MEDICINE REPORTS
ISSN:
1791-2997
年:
2016
卷:
14
期:
2
页码:
1501-1508
基金类别:
This research was supported by the National Natural Science Foundation of China (grant no. 81200881) and the Hunan Provincial Natural Science Foundation of China (grant no. 12JJ6073)
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
Fragile X mental retardation protein (FMRP), fragile X related 1 protein (FXR1P) and FXR2P are the members of the FMR protein family. These proteins contain two KH domains and a RGG box, which are characteristic of RNA binding proteins. The absence of FMRP, causes fragile X syndrome (FXS), the leading cause of hereditary mental retardation. FXR1P is expressed throughout the body and important for normal muscle development, and its absence causes cardiac abnormality. To investigate the functions of FXR1P, a screen was performed to identify FXR1P...

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