Improvement of spermogenesis impairment induced by high-fat diet in obese mice through pyrroloquinoline quinone regulation of glycolysis pathway

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成果类型：

期刊论文

作者：

Wei, Yanhong*;Huang, Qiumei*;Fu, Zhenhui*;Wang, Rutong*;Zhou, Runtang*;...

通讯作者：

Wei, Yanhong;Huang, Qiumei;Fu, Zhenhui;Wang, Rutong;Zhou, Runtang;Le, Jianghua;Hu, Linlin;Lei, Xiaocan

作者机构：

[Wei, Yanhong] Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi, Department of Obstetrics and Gynecology, Department of reproductive medicine Center, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China. Electronic address: 2514138998@qq.com

[Huang, Qiumei] Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi, Department of Obstetrics and Gynecology, Department of reproductive medicine Center, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China. Electronic address: 17877325360@163.com

[Fu, Zhenhui] Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi, Department of Obstetrics and Gynecology, Department of reproductive medicine Center, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China. Electronic address: fuzhenhui10@163.com

[Wang, Rutong] Institute of Clinical Anatomy & Reproductive Medicine Department of Histology and Embryology Hengyang Medical School University of South China Hengyang, Hunan 421001, China. Electronic address: 18754723679@163.com

[Zhou, Runtang] Institute of Clinical Anatomy & Reproductive Medicine Department of Histology and Embryology Hengyang Medical School University of South China Hengyang, Hunan 421001, China. Electronic address: 2662580138@qq.com

通讯机构：

[Huang, Qiumei; Hu, Linlin; Fu, Zhenhui; Wei, Yanhong] K

[Wang, Rutong; Lei, Xiaocan; Zhou, Runtang] I

[Le, Jianghua] D

Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi, Department of Obstetrics and Gynecology, Department of reproductive medicine Center, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China. Electronic address:

Institute of Clinical Anatomy & Reproductive Medicine Department of Histology and Embryology Hengyang Medical School University of South China Hengyang, Hunan 421001, China. Electronic address:

语种：

英文

关键词：

Gut microbiome;Male infertility;Metabolomics;Network pharmacology;Obesity;Pyrroloquinoline quinone

期刊：

JOURNAL OF NUTRITIONAL BIOCHEMISTRY

ISSN：

0955-2863

年：

2026

卷：

147

页码：

110066

DOI：

10.1016/j.jnutbio.2025.110066

基金类别：

CRediT authorship contribution statement Qiumei Huang: Writing – original draft, Visualization. Yanhong Wei: Validation, Data curation. Zhenhui Fu: Validation, Formal analysis. Rutong Wang: Validation. Runtang Zhou: Investigation. Xiaocan Lei: Writing – review & editing, Methodology, Conceptualization. Jianghua Le: acquisition. Linlin Hu: Methodology, Conceptualization. This study was supported by the National Natural Science Foundation of China ( 82360292 ), the Nature Science Foundation of Guangxi (NO.2022GXNSFAA103023, No. 2023GXNSFAA026043), the Guangxi Medical and Health Key Discipline Construction Project and the Students Innovation and Entrepreneurship Training Program of the National College (202310555101).

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

This study employed an obese mouse model to investigate the effects of pyrroloquinoline quinone (PQQ) intervention on reproductive physiology and glycolytic pathways. Our findings demonstrate that PQQ markedly enhanced glycolytic activity in obese mice, promoting glucose breakdown and metabolism to improve energy supply efficiency. These metabolic improvements correlated with significant support for reproductive system functionality. Mechanistic analyses revealed PQQ's potential to augment mitochondrial respiration, ameliorate mitochondrial dysfunction, and counteract obesity-associated inflam...

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Improvement of spermogenesis impairment induced by high-fat diet in obese mice through pyrroloquinoline quinone regulation of glycolysis pathway

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