Analysis of mRNA Expression Patterns in Peripheral Blood Cells of 3 Patients With Cancer After the First Fraction of 2 Gy Irradiation: An Integrated Case Report and Systematic Review

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成果类型：

期刊论文

作者：

Nie, Yue-Hua;Liu, Xiao-Dan;Huang, Ruixue*;Xie, Da-Fei;Yin, Wen-Jun;...

通讯作者：

Huang, Ruixue;Zhou, Ping-Kun

作者机构：

[Nie, Yue-Hua; Yin, Wen-Jun; Yu, Zi-Jian] Univ South China, Affiliated Hosp 1, Dept Tumor Radiotherapy, Hengyang, Peoples R China.

[Guan, Hua; Liu, Xiao-Dan; Zhou, Ping-Kun; Xie, Da-Fei] Beijing Inst Radiat Med, Dept Radiat Biol, Beijing Key Lab Radiobiol, Beijing, Peoples R China.

[Huang, Ruixue] Cent S Univ, Dept Occupat & Environm Hlth, Changsha 410078, Hunan, Peoples R China.

[Zhou, Ping-Kun] Guangzhou Med Univ, Inst Chem Carcinogenesis, State Key Lab Resp Dis, Guangzhou, Guangdong, Peoples R China.

[Zhou, Ping-Kun] Beijing Inst Radiat Med, 27 Taiping Rd, Beijing 100850, Peoples R China.

通讯机构：

[Huang, Ruixue] C

[Zhou, Ping-Kun] B

Cent S Univ, Dept Occupat & Environm Hlth, Changsha 410078, Hunan, Peoples R China.

Beijing Inst Radiat Med, 27 Taiping Rd, Beijing 100850, Peoples R China.

语种：

英文

关键词：

mRNA expression;microarray analysis;radiation therapy;radiological toxicity

期刊：

Dose-Response

ISSN：

1559-3258

年：

2019

卷：

期：

页码：

1559325819833474

DOI：

10.1177/1559325819833474

基金类别：

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study is supported by grants from National Key Basic Research Program (973 Program) of MOST, China (Grant No. 2015CB910601), the National Natural Science Foundations of China (Grant No. 31530085, 31870847, U1432248, U1803124), and Natural Science Foundation of Hunan Province (Grant No. 2018JJ3166)

机构署名：

本校为第一机构

摘要：

Background: Radiation therapy induces acute and chronic radiological toxicity, in particular hematological toxicity (HT). This study aimed to explore the mechanistic clue and potential predictors at the messenger RNA (mRNA) level. Materials and Methods: Peripheral blood was collected from 3 patients with cervical cancer (CC), nasopharynx cancer (NC), and tongue cancer (TC) after the first 2 Gy fraction of radiotherapy (RT). High-throughput sequencing was used to assess mRNA profiles. Results: Eleven genes, such as ALAS2(5-aminolevulinate syntha...

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Analysis of mRNA Expression Patterns in Peripheral Blood Cells of 3 Patients With Cancer After the First Fraction of 2 Gy Irradiation: An Integrated Case Report and Systematic Review

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