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Molecular and Cellular Functions of the Linker Histone H1.2

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成果类型:
期刊论文
作者:
Lai, Shuting;Jia, Jin;Cao, Xiaoyu;Zhou, Ping-Kun*;Gao, Shanshan*
通讯作者:
Zhou, Ping-Kun;Gao, Shanshan
作者机构:
[Lai, Shuting; Zhou, Ping-Kun] Univ South China, Sch Publ Hlth, Inst Environm Med & Radiat Hyg, Hengyang, Peoples R China.
[Cao, Xiaoyu; Lai, Shuting; Gao, Shanshan; Zhou, Ping-Kun; Jia, Jin] Beijing Inst Radiat Med, Dept Radiat Biol, Beijing Key Lab Radiobiol, Beijing, Peoples R China.
[Jia, Jin] Univ South China, Sch Med, Hengyang, Peoples R China.
[Cao, Xiaoyu] Hebei Univ, Sch Life Sci, Baoding, Peoples R China.
通讯机构:
[Zhou, Ping-Kun] U
[Zhou, PK; Gao, SS] B
Univ South China, Sch Publ Hlth, Inst Environm Med & Radiat Hyg, Hengyang, Peoples R China.
Beijing Inst Radiat Med, Dept Radiat Biol, Beijing Key Lab Radiobiol, Beijing, Peoples R China.
语种:
英文
关键词:
Linker histone H1.2;DNA damage response;post-translational modification;Gene Expression;Cancer
期刊:
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
ISSN:
2296-634X
年:
2022
卷:
9
页码:
773195
基金类别:
This work was supported by grants from the National Natural Science Foundation of China (32101165).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
公共卫生学院
摘要:
Linker histone H1.2, which belongs to the linker histone family H1, plays a crucial role in the maintenance of the stable higher-order structures of chromatin and nucleosomes. As a critical part of chromatin structure, H1.2 has an important function in regulating chromatin dynamics and participates in multiple other cellular processes as well. Recent work has also shown that linker histone H1.2 regulates the transcription levels of certain target genes and affects different processes as well, such as cancer cell growth and migration, DNA duplication and DNA repair. The present work briefly sum...

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