期刊论文

Li, Lanfang;Chen, Linxi

英文

DNA AND CELL BIOLOGY

1044-5498

2017

36

8

611-618

10.1089/dna.2016.3574

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81503074, 81470434, 81670265]; Hunan Provincial Natural Science FoundationNatural Science Foundation of Hunan Province [2017JJ2227]; Construct Program of the Key Discipline in Hunan Province; Hunan Province Cooperative innovation Center for Molecular Target New Drug Study (Hunan Provincial Education Department document) [2014-405]; Administration of Traditional Chinese Medicine of Hunan Province [201578]; Health and Family planning commission of Hunan Province [B2015-48]

本校为第一且通讯机构

Apelin, an endogenous ligand for apelin receptor (APJ), is reported to be involved in cardiomyocyte hypertrophy. In this study, we explored the mechanism of cardiomyocyte hypertrophy induced by apelin-13/APJ system. Left ventricular hypertrophy (LVH) rat model was established by constricting the abdominal aorta. Western blots were used for protein expression in LVH rats and cultured H9c2 cardiomyocytes. Transmission electron microscopy (TEM) was used to monitor morphological features of cells. In addition, the diameter and volume of H9c2 cells ...