ROS‐mediated PERK‐CHOP pathway plays an important role in cadmium‐induced HepG2 cells apoptosis

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成果类型：

期刊论文

作者：

Zhaohui, Cao;Cifei, Tang;Di, Huang;Weijia, Zeng;Cairui, Han;...

通讯作者：

Xiaobo, H

作者机构：

[Cairui, Han; Zhaohui, Cao; Weijia, Zeng; Di, Huang; Xiaobo, Hu; Cifei, Tang; Zecong, Li] Univ South China, Sch Basic Med, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang, Peoples R China.

[Zhaohui, Cao; Di, Huang; Xiaobo, Hu; Cifei, Tang] Univ South China, Crit Human Dis Prevent Hunan Prov, Key Lab Ecol Environm, Dept Educ, Hengyang, Peoples R China.

[Xiaobo, Hu] Univ South China, Sch Basic Med, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang 421001, Peoples R China.

通讯机构：

[Xiaobo, H ] U

Univ South China, Sch Basic Med, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

apoptosis;cadmium;ER stress;oxidative stress

期刊：

ENVIRONMENTAL TOXICOLOGY

ISSN：

1520-4081

年：

2023

卷：

期：

页码：

2271-2280

DOI：

10.1002/tox.23866

基金类别：

This work was supported by the Nature Science Fund of Hunan Province (No. 2021JJ30585 and 2021JJ30598), the Education Department of Hunan Province Project (No. 21C0280), Undergraduate Research and Innovation Project of University of South China (No. S202110555325, X202110555528, X202110555541, and 2022X10555136).

机构署名：

本校为第一且通讯机构

院系归属：

化学化工学院

药学与生物科学学院

摘要：

Cadmium (Cd) is a common heavy metal that is highly toxic to the liver, however, the exact mechanism underlying this damage accompanied by apoptosis has not been thoroughly demonstrated. In this study, we found that Cd exposure significantly reduced cell viability, including the increased populations of apoptotic cells and caspase-3/-7/-12 activation in HepG2 cells. Mechanistically, Cd initiated oxidative stress via elevating reactive oxygen species (ROS) levels, leading to oxidative damage in HepG2 cells. Simultaneously, Cd exposure induced en...

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ROS‐mediated PERK‐CHOP pathway plays an important role in cadmium‐induced HepG2 cells apoptosis

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