Construction and protective immunogenicity of DNA vaccine pNMB0315 against Neisseria meningitidis serogroup B

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wu, Xiaoxia;Li, Kaiming;Xie, Meihua;Yu, Minjun;Tang, Shuangyang;...

通讯作者：

Hu, Sihai

作者机构：

[Wu, Xiaoxia; Hu, Sihai; Li, Zhenyu; Li, Kaiming; Xie, Meihua; Yu, Minjun; Tang, Shuangyang] Univ South China, Lab Antiinfect Immun, Pathogen Biol Inst, Coll Basic Med, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Li, Kaiming] Cent Hosp Hengyang City, Clin Lab, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Hu, Sihai] U

Univ South China, Lab Antiinfect Immun, Pathogen Biol Inst, Coll Basic Med, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

CpG oligodeoxynucleotide;DNA vaccine;gamma interferon;genomic DNA;immunoglobulin G;immunoglobulin G1;immunoglobulin G2a;interleukin 4;Meningococcus vaccine;Neisseria meningitidis serogroup B outer membrane protein 0315;outer membrane protein;unclassified drug;bacterial antigen;bacterial protein;bacterium antibody;cytokine;DNA vaccine;immunoglobulin G;animal experiment;animal model;antibody titer;Article;bacterial strain;bactericidal activity;cellular immunity;comparative study;controlled study;COS-7 cell line;DNA immunization;eukaryotic cell;female;genetic transfection;humoral immunity;in vitro study;in vivo study;meningococcosis;mouse;Neisseria meningitidis;newborn;nonhuman;protein blood level;RAW 264.7 cell line;recombinant plasmid;survival rate;vaccine immunogenicity;animal;Bagg albino mouse;blood;Chlorocebus aethiops;CV-1 cell line;genetics;hamster;immunology;meningococcosis;metabolism;Neisseria meningitidis;pathogenicity;plasmid;serotype;veterinary;Animals;Antibodies, Bacterial;Antigens, Bacterial;Bacterial Proteins;Cercopithecus aethiops;COS Cells;Cricetinae;Cytokines;Female;Immunoglobulin G;Meningococcal Infections;Mice;Mice, Inbred BALB C;Neisseria meningitidis;Plasmids;RAW 264.7 Cells;Serogroup;Survival Rate;Vaccines, DNA

期刊：

MOLECULAR MEDICINE REPORTS

ISSN：

1791-2997

年：

2018

卷：

期：

页码：

3178-3185

DOI：

10.3892/mmr.2017.8255

基金类别：

The present study was supported by The National Natural Science Foundation of China (grant no. 81172890), The Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (grant no. 2015-351) and The Construct Program of the Key Discipline in Hunan Province and Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control (grant no. 2014-5-2012-312). The authors thank Mrs. Chunxue Lu and Mr. Yukuai Zhang (University of South China, Hengyang, China) for their excellent technical assistance and advice.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Neisseria meningitidis (N. meningitidis) is a major cause of meningitis and sepsis. Capsular polysaccharide-based vaccines against serogroups A, C, Y, and W135 are available; however, the development of a vaccine against N. meningitidis serogroup B (NMB) has been problematic. NMB0315 is an outer membrane protein of NMB that may be a virulence factor for N. meningitidis and a possible target for functional bactericidal antibodies. The present study aimed to develop a potent DNA vaccine against NMB by cloning the NMB0135 gene into the pcDNA3.1(+)...

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Construction and protective immunogenicity of DNA vaccine pNMB0315 against Neisseria meningitidis serogroup B

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