Human umbilical cord mesenchymal stem cells improve the reserve function of perimenopausal ovary via a paracrine mechanism

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成果类型：

期刊论文

作者：

Li, Jia;Mao, QiuXian;He, JingJun;She, HaoQing;Zhang, Zhi*;...

通讯作者：

Yin, ChunYan;Zhang, Zhi

作者机构：

[Li, Jia] Guangdong Med Univ, Dept Obstet & Gynecol, Grad Coll, Zhanjiang 524023, Guangdong, Peoples R China.

[Yin, ChunYan; Li, Jia; Mao, QiuXian] Guangdong 2 Prov Peoples Hosp, Dept Obstet & Gynecol, 466 Xingangdong Rd, Guangzhou 510317, Guangdong, Peoples R China.

[He, JingJun] Guangdong 2 Prov Peoples Hosp, Dept Phys Examinat, 466 Xingangdong Rd, Guangzhou 510317, Guangdong, Peoples R China.

[She, HaoQing] NanHua Univ, Dept Obstet & Gynecol, Coll Med, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Zhi] Guangdong 2 Prov Peoples Hosp, Dept Lab Med, 466 Xingangdong Rd, Guangzhou 510317, Guangdong, Peoples R China.

通讯机构：

[Yin, ChunYan; Zhang, Zhi] G

Guangdong 2 Prov Peoples Hosp, Dept Obstet & Gynecol, 466 Xingangdong Rd, Guangzhou 510317, Guangdong, Peoples R China.

Guangdong 2 Prov Peoples Hosp, Dept Lab Med, 466 Xingangdong Rd, Guangzhou 510317, Guangdong, Peoples R China.

语种：

英文

关键词：

hUCMSCs;Perimenopausal;Ovarian reserve function;HGF;VEGF;IGF-1;Paracrine

期刊：

Stem Cell Research & Therapy

ISSN：

1757-6512

年：

2017

卷：

期：

页码：

1-11

DOI：

10.1186/s13287-017-0514-5

基金类别：

Medical Science and Technology Research Foundation of Guangdong Province [A2016497]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Human umbilical cord mesenchymal stem cells (hUCMSCs) are a type of pluripotent stem cell which are isolated from the umbilical cord of newborns. hUCMSCs have great therapeutic potential. We designed this experimental study in order to investigate whether the transplantation of hUCMSCs can improve the ovarian reserve function of perimenopausal rats and delay ovarian senescence. We selected naturally aging rats confirmed by vaginal smears as models of perimenopausal rats, divided into the control group and the treatment group, and selected young...

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Human umbilical cord mesenchymal stem cells improve the reserve function of perimenopausal ovary via a paracrine mechanism

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