期刊论文

Zhizhong Xie<&wdkj&>Shengsong Tang

英文

International Immunopharmacology

1567-5769

2022

106

108597

10.1016/j.intimp.2022.108597

Angiogenesis, the process by which new capillary blood vessels or lymphatic vessels grow from pre-existing vessel and elongates to form a new vessel, is essential for growth and metastasis of many solid tumors [65]. TECs differentiation, migration and proliferation account for angiogenesis. IL-8 and VEGF, Members of the angiogenic factor family, play important roles in TECs development and angiogenesis [66]. Lactic acid is an energy-rich metabolite capable of serving as a precursor for ATP

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Warburg effect is one of the hallmarks of tumor favoring the suppression of normal oxidative phosphorylation (OxPhos) and the adaptation to hypoxia. In addition to providing continuous energy to meet the demands of tumors, accelerated Warburg effect also produces a large amount of lactic acid. Lactic acid shuttles between different cell populations within the tumor microenvironment (TME) and confers tumor cells to interact with surrounding cells, which has emerged as a new phenomenon in the field of tumor biology and tumorigenesis. Lactic acid not only fulfills the energetic demands of stromal...