Gu Han Yang Sheng Jing improves major depressive disorder via attenuating neuroinflammation by inhibiting AKT1/p65 signaling pathway based on network pharmacology analysis and experimental validation.

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成果类型：

期刊论文

作者：

Li, Xun;Yang, San-Qiao;Zhang, Hai-Jun;Zhong, Yuan;Wen, Ge;...

通讯作者：

Xiao, ZJ;Kang, X;Wen, G

作者机构：

[Li, Xun; Xiao, Zi-Jian; Xiao, ZJ] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Neurol, Hengyang 421001, Hunan, Peoples R China.

[Yang, San-Qiao] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Anesthesiol, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Hai-Jun] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Cardiol, Hengyang 421001, Hunan, Peoples R China.

[Kang, Xuan] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Metab & Endocrinol, Hengyang 421001, Hunan, Peoples R China.

[Wen, Ge; Zhong, Yuan] TUS PHARMA Grp Co Ltd, Hengyang, Peoples R China.

通讯机构：

[Kang, X ; Xiao, ZJ ] U

[Wen, G ] T

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Neurol, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Metab & Endocrinol, Hengyang 421001, Hunan, Peoples R China.

TUS PHARMA Grp Co Ltd, Hengyang, Peoples R China.

语种：

英文

关键词：

AKT1/p65 signaling pathway;Gu Han Yang Sheng Jing;Major depressive disorder;Network pharmacology;Neuroinflammation

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2025

卷：

352

页码：

120146

DOI：

10.1016/j.jep.2025.120146

基金类别：

National Natural Science Foundation China [82201355]; Natural Science Foundation of Hunan Province [2022JJ50165, 2023JJ30539]; Clinical medical technology innovation guidance project in Hunan Province [2021SK51816]; Hunan Science and Technology Innovation Program; Hengyang City Science and Technology Plan Project Funding; Guhan Special Project of Hunan Provincial Natural Science Foundation [2025JJ90237]; Scientific Research Project of Hunan Provincial Health Commission [202103010216]; [2023RC3256]; [202330016373]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Ethnopharmacological relevance Previous studies indicate that Gu Han Yang Sheng Jing (GHYSJ) exhibits neuroprotective properties in the central nervous system, but the protective effect of GHYSJ on major depressive disorder (MDD) and the precise mechanism underlying its protective effects remains unclear. Previous studies indicate that Gu Han Yang Sheng Jing (GHYSJ) exhibits neuroprotective properties in the central nervous system, but the protective effect of GHYSJ on major depressive disorder (MDD) and the precise mechanism underlying its protective effects remains unclear. Aim of the study ...

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Gu Han Yang Sheng Jing improves major depressive disorder via attenuating neuroinflammation by inhibiting AKT1/p65 signaling pathway based on network pharmacology analysis and experimental validation.

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