Evaluation of a tandem Chlamydia psittaci Pgp3 multiepitope peptide vaccine against a pulmonary chlamydial challenge in mice

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成果类型：

期刊论文

作者：

Wang, Chuan;Li, Yumeng;Wang, Shuzhi;Yan, Xiaoliang;Xiao, Jian;...

通讯作者：

Wu, Yimou

作者机构：

[Lu, Chunxue; Wu, Yimou; Li, Yumeng; Chen, Yuqing; Zheng, Kang; Tan, Yuan; Yan, Xiaoliang; Wang, Chuan; Xiao, Jian] Univ South China, Hengyang Med Coll, Inst Pathogen Biol, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang, Peoples R China.

[Lu, Chunxue; Wu, Yimou; Li, Yumeng; Chen, Yuqing; Zheng, Kang; Tan, Yuan; Yan, Xiaoliang; Wang, Chuan; Xiao, Jian] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Wang, Shuzhi] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

[Yu, Jian] Univ South China, Hengyang Med Coll, Dept Expt Zool, Hengyang 421001, Peoples R China.

[Wu, Yimou] Univ South China, Hengyang Med Coll, Pathogen Biol Inst, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Wu, Yimou] U

Univ South China, Hengyang Med Coll, Pathogen Biol Inst, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

gamma interferon;interleukin 10;interleukin 12;interleukin 2;interleukin 4;interleukin 6;peptide vaccine;Pgp3 multiepitope peptide vaccine;unclassified drug;bacterial vaccine;bacterium antibody;cytokine;subunit vaccine;animal experiment;animal model;animal tissue;Article;Bagg albino mouse;cell proliferation;cellular immunity;Chlamydia psittaci;controlled study;cytokine release;drug effect;drug efficacy;drug screening;enzyme linked immunosorbent assay;female;humoral immunity;immune response;immunogenicity;infection control;lung infiltrate;mouse;nonhuman;ornithosis;pathogen load;priority journal;risk reduction;sequence homology;animal;chlamydiasis;lung;Animals;Antibodies, Bacterial;Bacterial Vaccines;Chlamydia Infections;Chlamydophila psittaci;Cytokines;Lung;Mice;Mice, Inbred BALB C;Vaccines, Subunit

期刊：

Microbial Pathogenesis

ISSN：

0882-4010

年：

2020

卷：

147

页码：

104256

DOI：

10.1016/j.micpath.2020.104256

基金类别：

This work was supported by the National Natural Science Foundation of China under Grant No. 81671986 and 31872643 , Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation under Grant No.2014–5, the Projects of Hunan Education Authorities under Grant No. 19C1573 and the Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (2015–351). This work was supported by the National Natural Science Foundation of China under Grant No.81671986 and 31872643, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation under Grant No.2014?5, the Projects of Hunan Education Authorities under Grant No. 19C1573 and the Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (2015?351).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Chlamydia psittaci is the pathogen of psittacosis, and it has emerged as a significant public health threat. Because most infections are easily overlooked, a vaccine is recognized as the best solution to control the spread of C. psittaci. Our previous study showed that Pgp3 protein is efficacious as a subunit vaccine while not the best candidate due to the negative effects. Thus, in this study, we tested the ability of a tandem epitope vaccine candidate designated SP based on Pgp3-dominant epitopes to induce protective immunity against pulmonary chlamydial infection. BALB/c mice were intraperi...

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Evaluation of a tandem Chlamydia psittaci Pgp3 multiepitope peptide vaccine against a pulmonary chlamydial challenge in mice

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