Protective efficacy of a treponema pallidum gpd dna vaccine vectored by chitosan nanoparticles and fused with interleukin-2

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhao, Feijun;Wang, Shiping;Zhang, Xiaohong;Gu, Weiming;Yu, Jian;...

通讯作者：

Wu, Yimou

作者机构：

[Yu, Jian; Wu, Yimou; Zhao, Feijun; Liu, Shuangquan; Zeng, Tiebing; Zhang, Yuejun] Univ S China, Pathogen Biol Inst, Hengyang 421001, Peoples R China.

[Gu, Weiming] Skin Dis & STD Hosp, Shanghai 200050, Peoples R China.

[Zhang, Xiaohong] Univ S China, Dept Histol & Embryol, Sch Med, Hengyang 421001, Peoples R China.

[Zhao, Feijun; Wang, Shiping] Cent S Univ, Xiangya Sch Med, Dept Parasitol, Changsha 410078, Hunan, Peoples R China.

通讯机构：

[Wu, Yimou] U

Univ S China, Pathogen Biol Inst, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Treponema pallidum;membrane protein;Gpd;IL-2;chitosan;nucleic acid vaccine;Treponema pallidium;protéine membranaire;Gpd;IL-2;chitosane;vaccin à acides nucléiques

期刊：

CANADIAN JOURNAL OF MICROBIOLOGY

ISSN：

0008-4166

年：

2012

卷：

期：

页码：

117-123

DOI：

10.1139/W11-115

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30800996]; Key Foundation of Hunan Province Science and Technology Department, China [2010FJ2008]; Natural Science Foundation of Hunan Province Science and Technology Department, China [11JJ9023, 2008HKJ22]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

In the present study, immunomodulatory responses of a DNA vaccine constructed by fusing Treponema pallidum (Tp) glycerophosphodiester phosphodiesterase (Gpd) to interleukin-2 (IL-2) and using chitosan (CS) nanoparticles as vectors were investigated. New Zealand white rabbits were immunized by intramuscular inoculation of control DNAs, Tp Gpd DNA vaccine, or Gpd-IL-2 fusion DNA vaccine, which were vectored by CS nanoparticles. Levels of the anti-Gpd antibodies and levels of IL-2 and interferon-gamma in rabbits were increased upon inoculation of Gpd-IL-2 fusion DNA vaccine, when compared with th...

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Protective efficacy of a treponema pallidum gpd dna vaccine vectored by chitosan nanoparticles and fused with interleukin-2

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