Lower dose of metformin combined with artesunate induced autophagy-dependent apoptosis of glioblastoma by activating ROS-AMPK-mTOR axis

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成果类型：

期刊论文

作者：

Ding, Wencong;Liao, Lingxiao;Liu, Jia;Zhao, Jiaxing;Tang, Qiongyan;...

通讯作者：

Liao, YS;Tang, QY

作者机构：

[Zhao, Jiaxing; Liao, Yongshi; Ding, Wencong] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Neurosurg, Hengyang 421002, Hunan, Peoples R China.

[Liao, Lingxiao] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Pharm, Hengyang 421002, Hunan, Peoples R China.

[Tang, Qiongyan] Univ South China, Affiliated Nanhua Hosp, Clin Res Inst, Hengyang Med Sch, Hengyang 421002, Hunan, Peoples R China.

[Tang, Qiongyan] Zhengzhou Univ, Affiliated Hosp 1, Dept Neurol, Zhengzhou 450052, Henan, Peoples R China.

通讯机构：

[Liao, YS ] U

[Tang, QY ] Z

Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Neurosurg, Hengyang 421002, Hunan, Peoples R China.

Zhengzhou Univ, Affiliated Hosp 1, Dept Neurol, Zhengzhou 450052, Henan, Peoples R China.

语种：

英文

关键词：

Artesunate;Autophagy;Autophagy-dependent apoptosis;Glioblastoma;Metformin

期刊：

Experimental Cell Research

ISSN：

0014-4827

年：

2023

卷：

430

期：

页码：

113691

DOI：

10.1016/j.yexcr.2023.113691

基金类别：

This study was supported by Natural Science Foundation of Hunan Province ( 2021JJ70044 ).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Glioblastoma multiform (GBM), one of the most common, aggressive primary brain tumours, demonstrates resistance to radiotherapy and chemotherapy after surgical resection and treatment failure. Metformin (MET) has been shown to suppress the proliferative capacity and invasion ability of GBM cells by activating AMPK and inhibiting mTOR, but the effective dose exceeded the maximum tolerated dose. Artesunate (ART) can exert certain anti-tumour effects by activating the AMPK-mTOR axis and inducing autophagy in tumour cells. Therefore, this study investigated the effects of MET combined with ART com...

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Lower dose of metformin combined with artesunate induced autophagy-dependent apoptosis of glioblastoma by activating ROS-AMPK-mTOR axis

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