This study was supported by the National Basic Research Program (973 Program) (Nos. 2012CB944601 , 2012CB517902 and 2011CB510002 to Hong Jiang), the National Natural Science Foundation of China (Nos. 81410308019 , 81471156 , 81271260 , 30971585 to Hong Jiang; No. 31401135 to Rong Qui), Hunan Funds for Distinguished Young Scientist (No. 14JJ1008 to Hong Jiang), Xinjiang Natural Science Foundation (No. 201318101-4 to Hong Jiang), Natural Science Foundation of Hunan Province (No. 2012SK3194 to Wei Zhuang), the Undergraduate Innovation Project of Central South University (No. YB13028 , 201410533324 to Hong Jiang), Graduate Innovation Project of Central South University (No. 2014zzts078 to Zhao Chen), Research project of the First People's Hospital of Chenzhou (No. N2014-017 , to Fengzhen Huang) and High-level medical personel of Hunan province “225” Project.