Hydrogen Sulfide Inhibits Formaldehyde-Induced Senescence in HT-22 Cells via Upregulation of Leptin Signaling

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成果类型：

期刊论文

作者：

Zhu, Wei-Wen;Ning, Min;Peng, Yi-Zhu;Tang, Yi-Yun;Kang, Xuan;...

通讯作者：

Zhan, Ke-Bin;Tang, Xiao-Qing

作者机构：

[Zhan, Ke-Bin; Peng, Yi-Zhu; Zhan, KB; Tang, XQ; Tang, Xiao-Qing; Zou, Wei; Zhu, Wei-Wen; Kang, Xuan; Ning, Min; Tang, Yi-Yun; Zhang, Ping] Univ South China, Hengyang Med Coll, Inst Neurosci, 28 W Changsheng Rd, Hengyang 42100, Hunan, Peoples R China.

[Zhan, Ke-Bin; Peng, Yi-Zhu; Ning, Min] Univ South China, Affiliated Hosp 2, Dept Neurol, 35 Jiefang Rd, Hengyang 421001, Hunan, Peoples R China.

[Kang, Xuan] Univ South China, Affiliated Hosp 1, Dept Endocrinol, Hengyang 42100, Hunan, Peoples R China.

[Zou, Wei; Zhang, Ping] Univ South China, Affiliated Nanhua Hosp, Dept Neurol, Hengyang 421001, Hunan, Peoples R China.

[Tang, Xiao-Qing] Univ South China, Affiliated Hosp 1, Inst Neurol, Hengyang 42100, Hunan, Peoples R China.

通讯机构：

[Zhan, KB; Tang, XQ; Zhan, Ke-Bin; Tang, Xiao-Qing] U

Univ South China, Hengyang Med Coll, Inst Neurosci, 28 W Changsheng Rd, Hengyang 42100, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 2, Dept Neurol, 35 Jiefang Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 1, Inst Neurol, Hengyang 42100, Hunan, Peoples R China.

语种：

英文

关键词：

beta galactosidase;cyclin dependent kinase inhibitor 1;cyclin dependent kinase inhibitor 2A;formaldehyde;hydrogen sulfide;leptin;leptin receptor;Cdkn1a protein, mouse;Cdkn2a protein, mouse;cyclin dependent kinase inhibitor 1A;cyclin dependent kinase inhibitor 2A;formaldehyde;hydrogen sulfide;leptin;leptin receptor;sodium bisulfide;sulfide;animal cell;apoptosis;Article;cell growth;cell proliferation;cell viability;cell viability assay;concentration (parameter);controlled study;down regulation;flow cytometry;HT22 cell line;in vitro study;mouse;neuroprotection;neurotoxicity;nonhuman;priority journal;protein expression;senescence;signal transduction;staining;trypan blue assay;upregulation;Western blotting;animal;biosynthesis;cell aging;cell division;cell line;cytology;degenerative disease;drug effect;gene expression regulation;genetics;hippocampus;metabolism;nerve cell;physiology;pollutant;signal transduction;toxicity;tumor suppressor gene;Animals;Apoptosis;Cell Division;Cell Line;Cellular Senescence;Cyclin-Dependent Kinase Inhibitor p16;Cyclin-Dependent Kinase Inhibitor p21;Environmental Pollutants;Formaldehyde;Gene Expression Regulation;Genes, p16;Hippocampus;Hydrogen Sulfide;Leptin;Mice;Neurodegenerative Diseases;Neurons;Receptors, Leptin;Signal Transduction;Sulfides;Up-Regulation

期刊：

NeuroMolecular Medicine

ISSN：

1535-1084

年：

2019

卷：

期：

页码：

192-203

DOI：

10.1007/s12017-019-08536-8

基金类别：

This study is supported by Natural Science Foundation of China (81671057), the Major Research Topics of the Health and Family Planning Commission of Hunan province (A2017011), Hunan Provincial Innovation Foundation for Postgraduate (CX2017B570, CX2018B619) and Postgraduate Research Innovation Foundation of University of South China (2018KYZ048). Acknowledgements This study is supported by Natural Science Foundation of China (81671057), the Major Research Topics of the Health and Family Planning Commission of Hunan province (A2017011), Hunan Provincial Innovation Foundation for Postgraduate (CX2017B570, CX2018B619) and Postgraduate Research Innovation Foundation of University of South China (2018KYZ048).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Abstract: It has been previously demonstrated that hydrogen sulfide (H2S) prevents formaldehyde (FA)-induced neurotoxicity. However, the exact mechanisms underlying this protection remain to be fully elucidated. Neuronal senescence is involved in FA-induced neurotoxicity. Leptin signaling has anti-aging function. The present work was to investigate the protection of H2S against FA-induced neuronal senescence and the mediatory role of leptin signaling. FA-exposed HT-22 cells were used as the vitro model of FA-induced neuronal senescence. The sen...

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Hydrogen Sulfide Inhibits Formaldehyde-Induced Senescence in HT-22 Cells via Upregulation of Leptin Signaling

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