Hydrogen Sulfide Inhibits High Glucose-Induced Neuronal Senescence by Improving Autophagic Flux via Up-regulation of SIRT1

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成果类型：

期刊论文

作者：

Wu, Lei;Chen, Ying;Wang, Chun-Yan;Tang, Yi-Yun;Huang, Hong-Lin*;...

通讯作者：

Tang, Xiao-Qing;Huang, Hong-Lin

作者机构：

[Tang, Xiao-Qing; Chen, Ying; Wu, Lei; Tang, Yi-Yun] Univ South China, Hengyang Med Coll, Inst Neurosci, Hengyang, Peoples R China.

[Wang, Chun-Yan; Tang, Xiao-Qing; Chen, Ying; Huang, Hong-Lin; Wu, Lei; Huang, HL; Tang, XQ] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, Hengyang, Peoples R China.

[Chen, Ying] Cent Hosp Hengyang, Dept Pharmacol, Hengyang, Peoples R China.

[Tang, Xiao-Qing; Kang, Xuan; Li, Xiang] Univ South China, Affiliated Hosp 1, Inst Neurol, Hengyang, Peoples R China.

[Xie, Yu-Rong] Univ South China, Coll Chem & Chem Engn, Hengyang, Peoples R China.

通讯机构：

[Tang, Xiao-Qing; Huang, HL; Tang, XQ] U

Univ South China, Hengyang Med Coll, Inst Neurosci, Hengyang, Peoples R China.

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, Hengyang, Peoples R China.

Univ South China, Affiliated Hosp 1, Inst Neurol, Hengyang, Peoples R China.

语种：

英文

关键词：

SIRT1;autophagic flux;high glucose;hydrogen sulfide;neuronal senescence

期刊：

FRONTIERS IN MOLECULAR NEUROSCIENCE

ISSN：

1662-5099

年：

2019

卷：

页码：

463556

DOI：

10.3389/fnmol.2019.00194

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81671057]; Natural Science Foundation of Hunan provinceNatural Science Foundation of Hunan Province [2019JJ50546, 2019JJ80101]

机构署名：

本校为第一且通讯机构

院系归属：

化学化工学院

医学院

药学与生物科学学院

摘要：

Hyperglycemia, a key characteristic and risk factor for diabetes mellitus (DM), causes neuronal senescence. Hydrogen sulfide (H2S) is a novel neuroprotectant. The present work was to investigate the potential effect of H2S on hyperglycemia-induced neuronal senescence and the underlying mechanisms. We found that NaHS, a donor of H2S, inhibited high glucose (HG)-induced cellular senescence in HT22 cells (an immortalized mouse hippocampal cell line), as evidenced by a decrease in the number of senescence associated-β-galactosidase (SA-β-gal) pos...

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Hydrogen Sulfide Inhibits High Glucose-Induced Neuronal Senescence by Improving Autophagic Flux via Up-regulation of SIRT1

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