Hydrogen sulfide inhibits PCSK9 expression through the PI3K/Akt-SREBP-2 signaling pathway to influence lipid metabolism in HepG2 cells

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成果类型：

期刊论文

作者：

Xiao, Jun;Bai, Xue-Qin;Liao, Ling;Zhou, Min;Peng, Juan;...

通讯作者：

Liu, Lu-Shan;Wang, Mei-Mei

作者机构：

[Jiang, Zhi-Sheng; Ren, Zhong; Xiao, Jun; Liao, Ling; Tang, Zhi-Han; Zhou, Min; Xiang, Qiong; Peng, Juan; Bai, Xue-Qin; Liu, Lu-Shan] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Wen, Hong-Yan] Hunan Univ Chinese Med, Med Coll, Changsha 410208, Hunan, Peoples R China.

[Wang, Mei-Mei] Univ South China, Affiliated Nanhua Hosp, Dept Pediat, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Liu, Lu-Shan; Wang, Mei-Mei] U

Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Nanhua Hosp, Dept Pediat, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

HepG2 cells;Hydrogen sulfide;Lipid metabolism;Low-density lipoprotein receptor;Phosphoinositide 3-kinase/protein kinase B;Proprotein convertase subtilisin/kexin type 9;Sterol regulatory element-binding protein 2

期刊：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

ISSN：

1107-3756

年：

2019

卷：

期：

页码：

2055-2063

DOI：

10.3892/ijmm.2019.4118

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81370376]; Natural Science Foundation of Hunan provinceNatural Science Foundation of Hunan Province [2018JJ2343, 2015JJ4097]; Key Project of the Educational Department of Hu-nan Province [15A137]; Visiting Scholar Foundation of Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education [QKLBST-2014-002, CQKLBST-2015-004]; first-class discipline in Hunan Province; Undergraduate Innovative Experiment Project [2018XJXZ369]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Hydrogen sulfide (H2S) is an endogenous gaseous signaling molecule that plays important roles in the cardiovascular system. In our previous studies, we demonstrated that H2S regulates lipid metabolism. In the present study, we aimed to explore the mechanisms through which H2S regulates lipid metabolism in HepG2 cells in vitro. Treatment of the HepG2 cells with H2S inhibited the expression of proprotein convertase subtilisin/kexin type 9 (PCSK9) and increased the level of lowdensity lipoprotein receptor (LDLR) in a time and dosedependent manner. The knockdown of PCSK9 by siRNA effectively incre...

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Hydrogen sulfide inhibits PCSK9 expression through the PI3K/Akt-SREBP-2 signaling pathway to influence lipid metabolism in HepG2 cells

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