期刊论文

Liu, LS;Wang, MM

英文

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

1107-3756

2019

43

5

2055-2063

10.3892/ijmm.2019.4118

The present study was supported by grants from the National Natural Science Foundation of china (no.81370376), the Natural Science Foundation of Hunan province (nos. 2018JJ2343 and 2015JJ4097), the Key Project of the Educational department of Hu-nan Province (no. 15A137), the Visiting Scholar Foundation of Key Laboratory of Biorheological Science and Technology (chongqing University), Ministry of Education (nos. cQKLBST-2014-002 and cQKLBST-2015-004), and the first‑class discipline in Hunan Province, and Undergraduate Innovative Experiment Project (no. 2018XJXZ369). The present study was supported by grants from the National Natural Science Foundation of China(no.81370376),the Natural Science Foundation of Hunan province (nos. 2018JJ2343 and 2015JJ4097), the Key Project of the Educational department of Hu-nan Province (no. 15A137), the Visiting Scholar Foundation of Key Laboratory of Biorheological Science and Technology (chongqing University), Ministry of Education (nos. cQKLBST-2014-002 and cQKLBST-2015-004), and the first‑class discipline in Hunan Province, and Undergraduate Innovative Experiment Project (no. 2018XJXZ369).

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Hydrogen sulfide (H2S) is an endogenous gaseous signaling molecule that plays important roles in the cardiovascular system. In our previous studies, we demonstrated that H2S regulates lipid metabolism. In the present study, we aimed to explore the mechanisms through which H2S regulates lipid metabolism in HepG2 cells in vitro. Treatment of the HepG2 cells with H2S inhibited the expression of proprotein convertase subtilisin/kexin type 9 (PcSK9) and increased the level of low-density lipoprotein receptor (LdLR) in a time- and dose-dependent mann...