The SPATA2/CYLD pathway contributes to doxorubicin-induced cardiomyocyte ferroptosis via enhancing ferritinophagy

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成果类型：

期刊论文

作者：

Zhou, Yuan-Jing;Duan, Dan-Qing;Lu, Li-Qun;Tang, Li-Jing;Zhang, Xiao-Jie;...

通讯作者：

Jun Peng

作者机构：

[Duan, Dan-Qing; Peng, Jun; Zhou, Yuan-Jing; Lu, Li-Qun; Zhang, Xiao-Jie] Cent South Univ, Xiangya Sch Pharmaceut Sci, Dept Pharmacol, Changsha 410078, Peoples R China.

[Zhou, Yuan-Jing] Guangdong Med Univ, Zhanjiang Cent Hosp, Dept Pharm, Zhanjiang 524045, Peoples R China.

[Tang, Li-Jing] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Pharm, Hengyang 421001, Hunan, Peoples R China.

[Luo, Xiu-Ju] Cent South Univ, Xiangya Hosp 3, Dept Lab Med, Changsha 410013, Peoples R China.

[Peng, Jun] Cent South Univ, Sch Pharmaceut Sci, Hunan Prov Key Lab Cardiovasc Res, Changsha 410078, Peoples R China.

通讯机构：

[Jun Peng] D

Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410078, China<&wdkj&>Hunan Provincial Key Laboratory of Cardiovascular Research, School of Pharmaceutical Sciences, Central South University, Changsha, 410078, China

语种：

英文

关键词：

CYLD;Doxorubicin;Ferritinophagy;Ferroptosis;NCOA4;SPATA2

期刊：

Chemico-Biological Interactions

ISSN：

0009-2797

年：

2022

卷：

368

页码：

110205

DOI：

10.1016/j.cbi.2022.110205

基金类别：

Author statement Yuan-Jing Zhou: Conceptualization, Methodology, Data curation, Writing-Original draft preparation; Dan-Qing Duan: Methodology, Data curation, Software, Validation; Li-Qun Lu: Data curation, Methodology; Li-Jing Tang: Visualization, Investigation; Xiao-Jie Zhang: Investigation, Validation; Xiu-Ju Luo: Conceptualization, Supervision, acquisition; Jun Peng: Supervision, Writing- Reviewing and Editing, acquisition.

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

Ferroptosis is an iron-dependent cell death and contributes to doxorubicin-induced cardiotoxicity, but the mechanisms behind intracellular iron overload in cardiomyocyte after administration of doxorubicin remain largely unknown. Ferritinophagy is a selective type of autophagy and could be a novel source for intracellular free iron. Spermatogenesis-associated protein 2 (SPATA2), a member of the TNF signaling pathway, can recruit cylindromatosis (CYLD, a deubiquitinating enzyme) to regulate cell death. This study aims to explore whether ferritin...

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The SPATA2/CYLD pathway contributes to doxorubicin-induced cardiomyocyte ferroptosis via enhancing ferritinophagy

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