Insights into N6-methyladenosine and programmed cell death in cancer

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成果类型：

期刊论文

作者：

Liu, Li;Li, Hui;Hu, Dingyu;Wang, Yanyan;Shao, Wenjun;...

通讯作者：

Zhang, Ji;Liu, Jing

作者机构：

[Liu, Li; Zhang, Ji; Yang, Shudong] Shenzhen Tradit Chinese Med Hosp, Dept Clin Lab, Shenzhen 518033, Guangdong, Peoples R China.

[Liu, Li; Wang, Yanyan; Zhang, Ji; Hu, Dingyu; Shao, Wenjun] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Rheumatol, Hengyang 421001, Hunan, Peoples R China.

[Liu, Jing; Li, Hui] Cent South Univ, Hunan Prov Key Lab Basic & Appl Hematol, Mol Biol Res Ctr, Changsha 410078, Hunan, Peoples R China.

[Liu, Jing; Li, Hui] Cent South Univ, Ctr Med Genet, Sch Life Sci, Changsha 410078, Hunan, Peoples R China.

[Li, Hui] Cent South Univ, Dept Dermatol, Xiangya Hosp,Hunan Key Lab Skin Canc & Psoriasis, Hunan Engn Res Ctr Skin Hlth & Dis,Xiangya Clin R, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Zhang, Ji] S

[Zhang, Ji] U

[Liu, Jing] C

Shenzhen Tradit Chinese Med Hosp, Dept Clin Lab, Shenzhen 518033, Guangdong, Peoples R China.

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Rheumatol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

N6-methyladenosine;Cancer;Apoptosis;Autophagy;Pyroptosis;Ferroptosis;Necroptosis

期刊：

Molecular Cancer

ISSN：

1476-4598

年：

2022

卷：

期：

页码：

1-16

DOI：

10.1186/s12943-022-01508-w

基金类别：

This work was funded by the National Natural Science Foundation of China (No. 82170138, 81870105, 81920108004, 81770107 and 82003286), National Key Research and Development Program of China (2018YFA0107800), Natural Science Foundation of Hunan Province (No. 2021JJ30022, 2019JJ20014 and 2021JJ40054), Scientific Research Fund Project of Hunan Provincial Health Commission (No. 20201921) and the Changsha Municipal Natural Science Foundation (No. kq20140421).

机构署名：

本校为通讯机构

摘要：

N6-methyladenosine (m6A) methylation, the most common form of internal RNA modification in eukaryotes, has gained increasing attention and become a hot research topic in recent years. M6A plays multifunctional roles in normal and abnormal biological processes, and its role may vary greatly depending on the position of the m6A motif. Programmed cell death (PCD) includes apoptosis, autophagy, pyroptosis, necroptosis and ferroptosis, most of which involve the breakdown of the plasma membrane. Based on the implications of m6A methylation on PCD, the regulators and functional roles of m6A methylati...

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Insights into N6-methyladenosine and programmed cell death in cancer

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