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Synthetic derivatives of chrysin and their biological activities

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成果类型:
期刊论文
作者:
Liu, Yunmei*;Song, Xiudao;He, Jun;Zheng, Xing;Wu, Houlv
通讯作者:
Liu, Yunmei
作者机构:
[Liu, Yunmei; Wu, Houlv; Song, Xiudao; Zheng, Xing] Univ South China, Inst Pharm & Pharmacol, Hengyang 421101, Peoples R China.
[He, Jun] Univ South China, Inst Chem & Chem Engn, Hengyang 421101, Peoples R China.
通讯机构:
[Liu, Yunmei] U
Univ South China, Inst Pharm & Pharmacol, Hengyang 421101, Peoples R China.
语种:
英文
关键词:
Chrysin derivatives;Anticancer activity;Anti-inflammatory activity;NO donors;Antimicrobial activity;Aromatase inhibitors
期刊:
Medicinal Chemistry Research
ISSN:
1054-2523
年:
2014
卷:
23
期:
2
页码:
555-563
基金类别:
Construct Program of the Key Discipline in Hunan Province; University of South China Postgraduate Innovative Funds [2012XCX12]
机构署名:
本校为第一且通讯机构
院系归属:
化学化工学院
药学与生物科学学院
摘要:
Chrysin is one of flavones constituents of Orocylumineicum vent. It has been a hot spot as a potential chemopreventive agent and as a natural molecule with numerous biological activities such as antioxidant, antitumor, antiviral, anti-hypertension, anti-diabetic, antibacterial, and so on in recent years. Because of its poor solubility, small intestinal absorption, and the rapid metabolism of glycosylation, a large number of efforts had been made by domestic and foreign researchers on designing its analogs and conjugates to obtain compounds with improved efficacy and selectivity for developing ...

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