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Protective immunity induced by recombinant protein CPSIT_p8 of Chlamydia psittaci

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成果类型:
期刊论文
作者:
Liang, Mingxing;Wen, Yating;Ran, Ou;Chen, Liesong;Wang, Chuan;...
通讯作者:
Chen, Chaoqun;Wu, Yimou
作者机构:
[Wu, Yimou; Li, Li; Xie, Yafeng; Liang, Mingxing; Chen, Liesong; Chen, Chaoqun; Wen, Yating; Wang, Chuan; Wu, YM; Ran, Ou] Univ South China, Pathogen Biol Inst, Coll Med, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Peoples R China.
[Wu, Yimou; Liang, Mingxing; Chen, Chaoqun; Wu, YM] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.
[Ran, Ou] Cent Hosp Xiangtan, Dept Clin Lab, Xiangtan 411100, Peoples R China.
[Zhang, Yang] Univ South China, Dept Pathol, Hengyang 421001, Peoples R China.
通讯机构:
[Chen, CQ; Wu, YM] U
[Chen, CQ; Wu, YM] H
Univ South China, Pathogen Biol Inst, Coll Med, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Peoples R China.
Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
C. psittaci;CPSIT_p8;Mouse;Plasmid protein;Protective immunity
期刊:
Applied Microbiology and Biotechnology
ISSN:
0175-7598
年:
2016
卷:
100
期:
14
页码:
6385-6393
基金类别:
This project was supported by the Natural Science Foundation of China (Grant No. 31270218, Grant No. 81171588) and the Special Foundation of Hunan Provincial Science and Technology Department (2013TT1003), the construct program of Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation (Grant No. 2014-5), and Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (Grant No. 2015-351).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Chlamydia psittaci is a zoonotic pathogen with a broad host range that can lead to severe respiratory and systemic disease in humans. Currently, an effective commercial vaccine against C. psittaci infection is not available. The chlamydial plasmid is an important virulence factor and encodes plasmid proteins that play important roles in chlamydial infection and the corresponding immune response. In this study, we assessed the efficacy of vaccination with plasmid proteins at preventing C. psittaci lung infection in a murine model. BALB/c mice we...

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