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Development of machine learning-based malignant pericardial effusion-related model in breast cancer: Implications for clinical significance, tumor immune and drug-therapy

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成果类型:
期刊论文
作者:
Zhan, Wendi;Hu, Haihong;Hao, Bo;Zhu, Hongxia;Yan, Ting;...
通讯作者:
Taolan Zhang
作者机构:
School of Pharmacy, Hengyang Medical College, University of South China, 28 Western Changsheng Road, Hengyang, Hunan, 421001, China
[Hao, Bo] Department of Pharmacy, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China
Phase I Clinical Trial Center, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China
[Yan, Ting] Department of Breast and Thyroid Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China
[Wang, Siyu] Department of Medical Oncology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China
通讯机构:
[Taolan Zhang] D
Department of Pharmacy, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China<&wdkj&>Phase I Clinical Trial Center, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China
语种:
英文
关键词:
Breast cancer;Immune infiltration;Malignant pericardial effusion;Prognostic model;Subtypes;Web-based tool
期刊:
Heliyon
ISSN:
2405-8440
年:
2024
卷:
10
期:
5
页码:
e27507
机构署名:
本校为第一且通讯机构
院系归属:
医学院
药学与生物科学学院
摘要:
BACKGROUND: Malignant pericardial effusion (MPE) is a common complication of advanced breast cancer (BRCA) and plays an important role in BRCA. This study is aims to construct a prognostic model based on MPE-related genes for predicting the prognosis of breast cancer. METHODS: The BRCA samples are analyzed based on the expression of MPE-related genes by using an unsupervised cluster analysis method. This study processes the data by least absolute shrinkage and selection operator and multivariate Cox analysis, and uses machine learning algorithms to construct BRCA prognostic model and develop w...

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