Cellular metabolism: a key player in cancer ferroptosis

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成果类型：

期刊论文

作者：

Jiang, Xianjie;Peng, Qiu;Peng, Mingjing;Oyang, Linda;Wang, Honghan;...

通讯作者：

Dai, Jie;Zhou, Yujuan;Liao, QJ

作者机构：

[Han, Yaqian; Xia, Longzheng; Zhou, Yujuan; Jiang, Xianjie; Oyang, Linda; Liao, Qianjin; Wang, Honghan; Liu, Qiang; Xu, Xuemeng; Yang, Wenjuan; Peng, Mingjing; Luo, Xia; Dai, Jie; Tang, Yanyan; Tan, Shiming; Zhou, YJ; Dai, J; Wu, Nayiyuan; Peng, Qiu; Lin, Jinguan] Cent South Univ, Hunan Canc Hosp, Hunan Key Lab Canc Metab, 283 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.

[Han, Yaqian; Xia, Longzheng; Zhou, Yujuan; Jiang, Xianjie; Oyang, Linda; Liao, Qianjin; Wang, Honghan; Liu, Qiang; Xu, Xuemeng; Yang, Wenjuan; Peng, Mingjing; Luo, Xia; Dai, Jie; Tang, Yanyan; Tan, Shiming; Zhou, YJ; Dai, J; Wu, Nayiyuan; Peng, Qiu; Lin, Jinguan] Cent South Univ, Affiliated Canc Hosp, Xiangya Sch Med, 283 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.

[Han, Yaqian; Zhou, Yujuan; Jiang, Xianjie; Oyang, Linda; Liu, Qiang; Peng, Mingjing; Luo, Xia; Liao, Qianjin; Tang, Yanyan; Wu, Nayiyuan; Peng, Qiu] Publ Serv Platform Tumor Organoids Technol, Changsha, Hunan, Peoples R China.

[Wang, Honghan; Dai, Jie] Cent South Univ, Hunan Canc Hosp, Dept Head & Neck Surg, Changsha, Hunan, Peoples R China.

[Xu, Xuemeng] Univ South China, Hengyang Med Sch, Hengyang, Hunan, Peoples R China.

通讯机构：

[Liao, QJ ; Zhou, YJ; Dai, J] C

Cent South Univ, Hunan Canc Hosp, Hunan Key Lab Canc Metab, 283 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.

Cent South Univ, Affiliated Canc Hosp, Xiangya Sch Med, 283 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

cancer therapy;cellular metabolism;ferroptosis inducer;ferroptosis

期刊：

CANCER COMMUNICATIONS

ISSN：

2523-3548

年：

2024

卷：

期：

页码：

185-204

DOI：

10.1002/cac2.12519

基金类别：

National Natural Science Foundation of China; Natural Science Foundation of Hunan Province [2023JJ60469, 2023JJ40413, 2023JJ30372, 2023JJ30375, 2022JJ80078, 2020JJ5336]; Research Project of Health Commission of Hunan Province [202203034978, 202109031837, 20201020]; Key Research and Development Program of Hunan Province [2022SK2051]; Hunan Provincial Science and Technology Department [2020TP1018]; Changsha Science and Technology Board [kh2201054]; Changsha Municipal Natural Science Foundation [kq2014209]; Ascend Foundation of National Cancer Center [NCC201909B06]; Hunan Cancer Hospital Climb Plan [ZX2020001-3, YF2020002]; Science and Technology Innovation Program of Hunan Province [2023RC3199, 2023SK4034, 2023RC1073]; China Postdoctoral Science Foundation [2022TQ0104, 2022M721118]; [82203233]; [82202966]; [82173142]; [82302987]; [82303534]; [81972636]

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本校为其他机构

摘要：

Cellular metabolism is the fundamental process by which cells maintain growth and self-renewal. It produces energy, furnishes raw materials, and intermediates for biomolecule synthesis, and modulates enzyme activity to sustain normal cellular functions. Cellular metabolism is the foundation of cellular life processes and plays a regulatory role in various biological functions, including programmed cell death. Ferroptosis is a recently discovered form of iron-dependent programmed cell death. The inhibition of ferroptosis plays a crucial role in tumorigenesis and tumor progression. However, the ...

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