The immune microenvironment in cartilage injury and repair

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Muzhe;Yin, Han;Yan, Zineng;Li, Huiyun;Wu, Jiang;...

通讯作者：

Liu, Shuyun;Guo, QY;Chen, ZW

作者机构：

[Yin, Han; Sui, Xiang; Li, Hao; Liu, Shuyun; Guo, Quanyi; Wei, Fu; Yan, Zineng; Guo, QY; Wang, Yue; Li, Muzhe; Wu, Jiang; Ning, Chao; Gao, Cangjian; Fu, Liwei; Liu, SY; Tian, Guangzhao; Jiang, Shuangpeng] Chinese Peoples Liberat Army Gen Hosp, Beijing Key Lab Regenerat Med Orthoped, Med Ctr 1,Inst Orthoped, Key Lab Musculoskeletal Trauma & War Injuries PLA, 28 Fuxing Rd, Beijing 100853, Peoples R China.

[Chen, Zhiwei; Chen, ZW; Li, Muzhe; Li, Huiyun] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Orthoped, Hengyang 421000, Peoples R China.

[Chen, Mingxue] Peking Univ, Beijing Jishuitan Hosp, Dept Orthped Surg, Clin Coll 4, Beijing 100035, Peoples R China.

通讯机构：

[Guo, QY ; Liu, SY] C

[Chen, ZW ] U

Chinese Peoples Liberat Army Gen Hosp, Beijing Key Lab Regenerat Med Orthoped, Med Ctr 1,Inst Orthoped, Key Lab Musculoskeletal Trauma & War Injuries PLA, 28 Fuxing Rd, Beijing 100853, Peoples R China.

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Orthoped, Hengyang 421000, Peoples R China.

语种：

英文

关键词：

Immune microenvironment;Inflammation;Cartilage repair;Cartilage injury;Biomaterials

期刊：

Acta Biomaterialia

ISSN：

1742-7061

年：

2022

卷：

140

页码：

23-42

DOI：

10.1016/j.actbio.2021.12.006

基金类别：

National Key R&D Program of China [2019YFA0110600]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81772319]; Chinese PLA General Hospital Medical Youth Program [QNC19042]; key project under the guidance of Hunan Provincial Health Commission [20200476, 20201907]

机构署名：

本校为通讯机构

摘要：

The ability of articular cartilage to repair itself is limited because it lacks blood vessels, nerves, and lymph tissue. Once damaged, it can lead to joint swelling and pain, accelerating the progression of osteoarthritis. To date, complete regeneration of hyaline cartilage exhibiting mechanical properties remains an elusive goal, despite the many available technologies. The inflammatory milieu created by cartilage damage is critical for chondrocyte death and hypertrophy, extracellular matrix breakdown, ectopic bone formation, and progression o...

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The immune microenvironment in cartilage injury and repair

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