\"Living Detergents\": an in Situ Detergent Tailoring Strategy for Efficient Membrane Protein Stabilization and Analysis - 成果

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"Living Detergents": an in Situ Detergent Tailoring Strategy for Efficient Membrane Protein Stabilization and Analysis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Dai, Yili;Yang, Meifang;Luo, Weiling;Qiu, Yanli;Zhou, Fang;...

通讯作者：

Yao, X;Tao, HC;Zhao, SW

作者机构：

[Yao, Xu; Dai, Yili; Zheng, Xing] Univ South China, Inst Pharm & Pharmacol, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Yang, Meifang; Tao, Houchao; Qiu, Yanli] Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, Shanghai Frontiers Sci Ctr TCM Chem Biol, Shanghai 201203, Peoples R China.

[Zhao, Fei; Luo, Weiling; Zhao, Suwen; Zhou, Fang] ShanghaiTech Univ, iHuman Inst, Shanghai 201210, Peoples R China.

[Zheng, Xing] Hunan Vocat Coll Sci & Technol, Dept Pharm, Changsha 410004, Hunan, Peoples R China.

通讯机构：

[Yao, X ] U

[Zhao, SW ; Tao, HC ] S

Univ South China, Inst Pharm & Pharmacol, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, Shanghai Frontiers Sci Ctr TCM Chem Biol, Shanghai 201203, Peoples R China.

ShanghaiTech Univ, iHuman Inst, Shanghai 201210, Peoples R China.

语种：

英文

关键词：

bioorthogonal reaction;living detergent;membrane proteins;micelle;Introduction

期刊：

CHEMISTRY-A EUROPEAN JOURNAL

ISSN：

0947-6539

年：

2025

卷：

期：

页码：

e202501128

DOI：

10.1002/chem.202501128

基金类别：

NSF of China; Shanghai University of Traditional Chinese Medicine; [21672147]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Detergents are essential molecular tools for membrane protein (MP) research, yet traditional detergents with static properties often fail to address the diverse and evolving needs of MP studies. To this end, this study introduces "living detergents", an innovative class of detergents equipped with functional tags that enable bioorthogonal modifications with externally introduced structural elements. This approach allows for not only the parallel generation of new detergents, but also in situ tuning of MP samples within freshly formed detergents. The efficacy of this strategy was demonstrated t...

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