\"Living Detergents\": an in Situ Detergent Tailoring Strategy for Efficient Membrane Protein Stabilization and Analysis - 成果

首页 > 成果 > 详情

"Living Detergents": an in Situ Detergent Tailoring Strategy for Efficient Membrane Protein Stabilization and Analysis

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Dai, Yili;Yang, Meifang;Luo, Weiling;Qiu, Yanli;Zhou, Fang;...

通讯作者：

Yao, X;Tao, HC;Zhao, SW

作者机构：

[Yao, Xu; Zheng, Xing; Dai, Yili] Univ South China, Inst Pharm & Pharmacol, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Qiu, Yanli; Tao, Houchao; Yang, Meifang] Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, Shanghai Frontiers Sci Ctr TCM Chem Biol, Shanghai 201203, Peoples R China.

[Luo, Weiling; Zhao, SW; Zhao, Suwen; Zhou, Fang; Zhao, Fei] ShanghaiTech Univ, iHuman Inst, Shanghai 201210, Peoples R China.

[Zheng, Xing] Hunan Vocat Coll Sci & Technol, Dept Pharm, Changsha 410004, Hunan, Peoples R China.

通讯机构：

[Yao, X ] U

[Zhao, SW ; Tao, HC ] S

Univ South China, Inst Pharm & Pharmacol, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, Shanghai Frontiers Sci Ctr TCM Chem Biol, Shanghai 201203, Peoples R China.

ShanghaiTech Univ, iHuman Inst, Shanghai 201210, Peoples R China.

语种：

英文

关键词：

Introduction;bioorthogonal reaction;living detergent;membrane proteins;micelle

期刊：

CHEMISTRY-A EUROPEAN JOURNAL

ISSN：

0947-6539

年：

2025

卷：

期：

页码：

e202501128

DOI：

10.1002/chem.202501128

基金类别：

NSF of China; Shanghai University of Traditional Chinese Medicine; [21672147]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Detergents are essential molecular tools for membrane protein (MP) research, yet traditional detergents with static properties often fail to address the diverse and evolving needs of MP studies. To this end, this study introduces "living detergents", an innovative class of detergents equipped with functional tags that enable bioorthogonal modifications with externally introduced structural elements. This approach allows for not only the parallel generation of new detergents, but also in situ tuning of MP samples within freshly formed detergents. The efficacy of this strategy was demonstrated t...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

"Living Detergents": an in Situ Detergent Tailoring Strategy for Efficient Membrane Protein Stabilization and Analysis

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问