期刊论文

Li, Lanfang

英文

Clinica Chimica Acta

0009-8981

2018

487

233-240

10.1016/j.cca.2018.10.011

Apoptosis is a process of programmed cell death, which is controlled by polygene (such as Bcl-2 family, caspase family, oncogene c-myc, tumor suppressor gene p53, etc.) to maintain the internal environment stability. Apoptosis is closely related to the process of aging. Elisa et al. demonstrate that anti-tumor compounds increase the expression of p53/p21 and induce apoptosis of human breast cancer cells [59]. Yu et al. reveal that the expression of pro-apoptotic protein Bax and caspase 3 are

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Apelin, an endogenous ligand for the G protein-coupled receptor APJ, is widely expressed in various organs. Recent research has indicated that the Apelin/APJ system plays an important role in aging. Apelin and APJ receptor expression are down-regulated with increasing age. In murine models, Apelin and APJ knockouts exhibit accelerated senescence whereas Apelin-restoration results in enhanced vigor and rejuvenated behavioral and circadian phenotypes. Furthermore, aged Apelin knockout mice develop progressive impairment of cardiac contractility associated with systolic dysfunction. Apelin is cru...